Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988097407> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1988097407 endingPage "20" @default.
- W1988097407 startingPage "15" @default.
- W1988097407 abstract "Toll-like receptors (TLRs) are essential molecules of the innate immune system that stimulate numerous inflammatory pathways and harmonize systemic defense against a wide array of pathogens. TLRs may also recognize a number of self-proteins and endogenous nucleic acids. Inappropriate stimulation of the TLR pathway by endogenous or exogenous ligands or as a consequence of mutation in the TLR genes may lead to induction and/or prolongation of autoimmune response and tissue injury. This study was designed to detect the TLR4 (Asp299Gly and Thr399Ile) gene polymorphism in Egyptian patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) as well as its correlation with disease activity. This study enrolled 50 patients who were attending the internal medicine and immunology out-patient clinic of Beni-Suef University Hospital. They were classified into three groups: 20 patients with RA, 20 patients with SLE, and 10 healthy controls. All studied persons were subjected to complete clinical evaluation, laboratory investigations, and detection of mutation in the TLR4 (Asp299Gly and Thr399Ile) gene by PCR technique. No individual in the RA patients group, the SLE patients group, or control population was identified carrying the Asp299Gly and Thr399Ile polymorphisms; in other words, all RA patients, SLE patients, and controls were with the same wild genotype. The similarity in genotype between the patients group and control population concluded that these two missense polymorphisms do not contribute to RA and SLE in a group of Egyptian population." @default.
- W1988097407 created "2016-06-24" @default.
- W1988097407 creator A5008768603 @default.
- W1988097407 creator A5040466199 @default.
- W1988097407 creator A5041400539 @default.
- W1988097407 creator A5052706711 @default.
- W1988097407 date "2014-03-01" @default.
- W1988097407 modified "2023-10-14" @default.
- W1988097407 title "Genotypic analysis of Asp299Gly and Thr399Ile polymorphisms of TLR4 in Egyptian patients with rheumatoid arthritis and systemic lupus erythematosus" @default.
- W1988097407 cites W112824597 @default.
- W1988097407 cites W1520365933 @default.
- W1988097407 cites W1522842079 @default.
- W1988097407 cites W1969364645 @default.
- W1988097407 cites W1977521192 @default.
- W1988097407 cites W1985711819 @default.
- W1988097407 cites W1988104967 @default.
- W1988097407 cites W1992913167 @default.
- W1988097407 cites W2014688976 @default.
- W1988097407 cites W2016217955 @default.
- W1988097407 cites W2030045317 @default.
- W1988097407 cites W2036767516 @default.
- W1988097407 cites W2047021787 @default.
- W1988097407 cites W2062645435 @default.
- W1988097407 cites W2070527591 @default.
- W1988097407 cites W2071680111 @default.
- W1988097407 cites W2074567151 @default.
- W1988097407 cites W2091426331 @default.
- W1988097407 cites W2091829446 @default.
- W1988097407 cites W2098279921 @default.
- W1988097407 cites W2101363646 @default.
- W1988097407 cites W2109491705 @default.
- W1988097407 cites W2118094114 @default.
- W1988097407 cites W2124419758 @default.
- W1988097407 cites W2128947649 @default.
- W1988097407 cites W2132497375 @default.
- W1988097407 cites W2134936041 @default.
- W1988097407 cites W2153872391 @default.
- W1988097407 cites W2163946030 @default.
- W1988097407 cites W2172258104 @default.
- W1988097407 doi "https://doi.org/10.4103/1110-7782.132884" @default.
- W1988097407 hasPublicationYear "2014" @default.
- W1988097407 type Work @default.
- W1988097407 sameAs 1988097407 @default.
- W1988097407 citedByCount "5" @default.
- W1988097407 countsByYear W19880974072021 @default.
- W1988097407 countsByYear W19880974072022 @default.
- W1988097407 crossrefType "journal-article" @default.
- W1988097407 hasAuthorship W1988097407A5008768603 @default.
- W1988097407 hasAuthorship W1988097407A5040466199 @default.
- W1988097407 hasAuthorship W1988097407A5041400539 @default.
- W1988097407 hasAuthorship W1988097407A5052706711 @default.
- W1988097407 hasBestOaLocation W19880974071 @default.
- W1988097407 hasConcept C104317684 @default.
- W1988097407 hasConcept C126322002 @default.
- W1988097407 hasConcept C135763542 @default.
- W1988097407 hasConcept C203014093 @default.
- W1988097407 hasConcept C2777077863 @default.
- W1988097407 hasConcept C2777575956 @default.
- W1988097407 hasConcept C54355233 @default.
- W1988097407 hasConcept C71924100 @default.
- W1988097407 hasConcept C86803240 @default.
- W1988097407 hasConceptScore W1988097407C104317684 @default.
- W1988097407 hasConceptScore W1988097407C126322002 @default.
- W1988097407 hasConceptScore W1988097407C135763542 @default.
- W1988097407 hasConceptScore W1988097407C203014093 @default.
- W1988097407 hasConceptScore W1988097407C2777077863 @default.
- W1988097407 hasConceptScore W1988097407C2777575956 @default.
- W1988097407 hasConceptScore W1988097407C54355233 @default.
- W1988097407 hasConceptScore W1988097407C71924100 @default.
- W1988097407 hasConceptScore W1988097407C86803240 @default.
- W1988097407 hasIssue "1" @default.
- W1988097407 hasLocation W19880974071 @default.
- W1988097407 hasLocation W19880974072 @default.
- W1988097407 hasOpenAccess W1988097407 @default.
- W1988097407 hasPrimaryLocation W19880974071 @default.
- W1988097407 hasRelatedWork W1971296504 @default.
- W1988097407 hasRelatedWork W2051531260 @default.
- W1988097407 hasRelatedWork W2056056959 @default.
- W1988097407 hasRelatedWork W2156283049 @default.
- W1988097407 hasRelatedWork W2219093167 @default.
- W1988097407 hasRelatedWork W2316954211 @default.
- W1988097407 hasRelatedWork W2317539666 @default.
- W1988097407 hasRelatedWork W2327246029 @default.
- W1988097407 hasRelatedWork W2950198226 @default.
- W1988097407 hasRelatedWork W4245782456 @default.
- W1988097407 hasVolume "26" @default.
- W1988097407 isParatext "false" @default.
- W1988097407 isRetracted "false" @default.
- W1988097407 magId "1988097407" @default.
- W1988097407 workType "article" @default.