FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988099644> ?p ?o ?g. }

• W1988099644 endingPage "350" @default.
• W1988099644 startingPage "339" @default.
• W1988099644 abstract "Background: The enzyme methylmalonyl-coenzyme A (CoA) mutase, an αβ heterodimer of 150 kDa, is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA.Results Reported here is the crystal structure at 2 å resolution of methylmalonyl-CoA mutase from Propionibacterium shermanii in complex with coenzyme B12 and with the partial substrate desulpho-CoA (lacking the succinyl group and the sulphur atom of the substrate). The coenzyme is bound by a domain which shares a similar fold to those of flavodoxin and the B12-binding domain of methylcobalamin-dependent methionine synthase. The cobalt atom is coordinated, via a long bond, to a histidine from the protein. The partial substrate is bound along the axis of a (β/α)8 TIM barrel domain.Conclusion The histidine–cobalt distance is very long (2.5 å compared with 1.95–2.2 å in free cobalamins), suggesting that the enzyme positions the histidine in order to weaken the metal–carbon bond of the cofactor and favour the formation of the initial radical species. The active site is deeply buried, and the only access to it is through a narrow tunnel along the axis of the TIM barrel domain." @default.
• W1988099644 created "2016-06-24" @default.
• W1988099644 creator A5006925296 @default.
• W1988099644 creator A5009329566 @default.
• W1988099644 creator A5010554991 @default.
• W1988099644 creator A5037553320 @default.
• W1988099644 creator A5039981398 @default.
• W1988099644 creator A5046627537 @default.
• W1988099644 creator A5063944769 @default.
• W1988099644 creator A5065876391 @default.
• W1988099644 creator A5079577008 @default.
• W1988099644 date "1996-03-01" @default.
• W1988099644 modified "2023-10-16" @default.
• W1988099644 title "How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 å resolution" @default.
• W1988099644 cites W1597509086 @default.
• W1988099644 cites W1749026910 @default.
• W1988099644 cites W1881281939 @default.
• W1988099644 cites W1963578268 @default.
• W1988099644 cites W1969058620 @default.
• W1988099644 cites W1969726382 @default.
• W1988099644 cites W1970714097 @default.
• W1988099644 cites W1972400761 @default.
• W1988099644 cites W1977594354 @default.
• W1988099644 cites W1981708356 @default.
• W1988099644 cites W1982306185 @default.
• W1988099644 cites W1988836698 @default.
• W1988099644 cites W1989098365 @default.
• W1988099644 cites W1993404146 @default.
• W1988099644 cites W2001641653 @default.
• W1988099644 cites W2010330695 @default.
• W1988099644 cites W2013083986 @default.
• W1988099644 cites W2016421990 @default.
• W1988099644 cites W2028231353 @default.
• W1988099644 cites W2038527823 @default.
• W1988099644 cites W2048558976 @default.
• W1988099644 cites W2050915803 @default.
• W1988099644 cites W2051134821 @default.
• W1988099644 cites W2057984729 @default.
• W1988099644 cites W2058691613 @default.
• W1988099644 cites W2071394380 @default.
• W1988099644 cites W2080476827 @default.
• W1988099644 cites W2087347863 @default.
• W1988099644 cites W2091979836 @default.
• W1988099644 cites W2095013747 @default.
• W1988099644 cites W2099101624 @default.
• W1988099644 cites W2101446086 @default.
• W1988099644 cites W2106315897 @default.
• W1988099644 cites W2114760287 @default.
• W1988099644 cites W2115350007 @default.
• W1988099644 cites W2117236066 @default.
• W1988099644 cites W2125427027 @default.
• W1988099644 cites W2139848390 @default.
• W1988099644 cites W2141603171 @default.
• W1988099644 cites W2155836823 @default.
• W1988099644 cites W2214192771 @default.
• W1988099644 cites W2334099322 @default.
• W1988099644 cites W2952847553 @default.
• W1988099644 cites W3206291250 @default.
• W1988099644 doi "https://doi.org/10.1016/s0969-2126(96)00037-8" @default.
• W1988099644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8805541" @default.
• W1988099644 hasPublicationYear "1996" @default.
• W1988099644 type Work @default.
• W1988099644 sameAs 1988099644 @default.
• W1988099644 citedByCount "441" @default.
• W1988099644 countsByYear W19880996442012 @default.
• W1988099644 countsByYear W19880996442013 @default.
• W1988099644 countsByYear W19880996442014 @default.
• W1988099644 countsByYear W19880996442015 @default.
• W1988099644 countsByYear W19880996442016 @default.
• W1988099644 countsByYear W19880996442017 @default.
• W1988099644 countsByYear W19880996442018 @default.
• W1988099644 countsByYear W19880996442019 @default.
• W1988099644 countsByYear W19880996442020 @default.
• W1988099644 countsByYear W19880996442021 @default.
• W1988099644 countsByYear W19880996442022 @default.
• W1988099644 countsByYear W19880996442023 @default.
• W1988099644 crossrefType "journal-article" @default.
• W1988099644 hasAuthorship W1988099644A5006925296 @default.
• W1988099644 hasAuthorship W1988099644A5009329566 @default.
• W1988099644 hasAuthorship W1988099644A5010554991 @default.
• W1988099644 hasAuthorship W1988099644A5037553320 @default.
• W1988099644 hasAuthorship W1988099644A5039981398 @default.
• W1988099644 hasAuthorship W1988099644A5046627537 @default.
• W1988099644 hasAuthorship W1988099644A5063944769 @default.
• W1988099644 hasAuthorship W1988099644A5065876391 @default.
• W1988099644 hasAuthorship W1988099644A5079577008 @default.
• W1988099644 hasBestOaLocation W19880996441 @default.
• W1988099644 hasConcept C181199279 @default.
• W1988099644 hasConcept C185592680 @default.
• W1988099644 hasConcept C197957613 @default.
• W1988099644 hasConcept C2777552656 @default.
• W1988099644 hasConcept C2778979354 @default.
• W1988099644 hasConcept C2779750884 @default.
• W1988099644 hasConcept C2779761754 @default.
• W1988099644 hasConcept C41183919 @default.
• W1988099644 hasConcept C55493867 @default.
• W1988099644 hasConcept C71240020 @default.
• W1988099644 hasConcept C8010536 @default.

• next