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- W1988103710 abstract "Diflerence spectrophotometry shows that double-stranded DNA produces mnarked changes in the absorption spectrum of chloroquine; only minor changes occur with single-stranded DNA. A DNA-chloroquine complex was demonstrated to sediment in the analytical ultracentrifuge. Chloroquine strongly elevated the thermal dissociation temperature, T(m), of DNA. It is concluded that the drug forms a complex with DNA by ionic interaction and stabilizes the helix." @default.
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- W1988103710 date "1965-09-03" @default.
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- W1988103710 title "DNA: Reaction with Chloroquine" @default.
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- W1988103710 doi "https://doi.org/10.1126/science.149.3688.1111" @default.
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