Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988126189> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1988126189 endingPage "149" @default.
- W1988126189 startingPage "145" @default.
- W1988126189 abstract "Autoantibodies are present in small quantities throughout most of the host life but increase with aging. It is unlikely they are the etiologic cause of aging. They probably do contribute to some of the pathologic changes seen in aging such as amyloid deposits. Autoantibodies, when they are part of a functioning microdebridement system, like other antibodies, are one method of increasing tissue debridement. Autoantibodies are a broad biologic phenomenon capable of doing far more good than harm. Inflammation weakens with aging and thus microdebridement is weakened. The immune system weakens with aging but is stimulated by the increasing accumulation of antigen derived from tissue debris. Autoantibodies are an attempt to enhance debridement in a weakening system. The autoantibody should not be condemned because of the failure of other aspects of the debridement system. Improving tissue debridement would not stop eventual senescence but it might decrease some of the pathologic and physiologic changes of aging and improve the quality of life. Improving tissue debridement is currently more attainable than altering the etiology of senescence. Factors promoting immunologic stimulation by tissue fractions are reviewed. The possible value of increasing tissue debridement in damage preceding arteriosclerotic vascular change is discussed. The role of the aging extracellular matrix in the weakening of ground substance and decreasing early cellular inflammation is reviewed." @default.
- W1988126189 created "2016-06-24" @default.
- W1988126189 creator A5038537961 @default.
- W1988126189 date "1990-06-01" @default.
- W1988126189 modified "2023-09-25" @default.
- W1988126189 title "Autoantibodies in aging: An attempt to correct a weakening debridement mechanism" @default.
- W1988126189 cites W1972517205 @default.
- W1988126189 cites W1998433547 @default.
- W1988126189 cites W2000749759 @default.
- W1988126189 cites W2062928121 @default.
- W1988126189 cites W2136481538 @default.
- W1988126189 cites W2156335790 @default.
- W1988126189 cites W2401469953 @default.
- W1988126189 cites W2418054607 @default.
- W1988126189 cites W2418522587 @default.
- W1988126189 cites W2484913532 @default.
- W1988126189 cites W2276359663 @default.
- W1988126189 doi "https://doi.org/10.1016/0306-9877(90)90038-g" @default.
- W1988126189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2198442" @default.
- W1988126189 hasPublicationYear "1990" @default.
- W1988126189 type Work @default.
- W1988126189 sameAs 1988126189 @default.
- W1988126189 citedByCount "6" @default.
- W1988126189 countsByYear W19881261892012 @default.
- W1988126189 countsByYear W19881261892013 @default.
- W1988126189 crossrefType "journal-article" @default.
- W1988126189 hasAuthorship W1988126189A5038537961 @default.
- W1988126189 hasConcept C126322002 @default.
- W1988126189 hasConcept C141071460 @default.
- W1988126189 hasConcept C142724271 @default.
- W1988126189 hasConcept C159654299 @default.
- W1988126189 hasConcept C163764329 @default.
- W1988126189 hasConcept C203014093 @default.
- W1988126189 hasConcept C2776914184 @default.
- W1988126189 hasConcept C2777438270 @default.
- W1988126189 hasConcept C500499127 @default.
- W1988126189 hasConcept C522857546 @default.
- W1988126189 hasConcept C71924100 @default.
- W1988126189 hasConcept C8891405 @default.
- W1988126189 hasConceptScore W1988126189C126322002 @default.
- W1988126189 hasConceptScore W1988126189C141071460 @default.
- W1988126189 hasConceptScore W1988126189C142724271 @default.
- W1988126189 hasConceptScore W1988126189C159654299 @default.
- W1988126189 hasConceptScore W1988126189C163764329 @default.
- W1988126189 hasConceptScore W1988126189C203014093 @default.
- W1988126189 hasConceptScore W1988126189C2776914184 @default.
- W1988126189 hasConceptScore W1988126189C2777438270 @default.
- W1988126189 hasConceptScore W1988126189C500499127 @default.
- W1988126189 hasConceptScore W1988126189C522857546 @default.
- W1988126189 hasConceptScore W1988126189C71924100 @default.
- W1988126189 hasConceptScore W1988126189C8891405 @default.
- W1988126189 hasIssue "2" @default.
- W1988126189 hasLocation W19881261891 @default.
- W1988126189 hasLocation W19881261892 @default.
- W1988126189 hasOpenAccess W1988126189 @default.
- W1988126189 hasPrimaryLocation W19881261891 @default.
- W1988126189 hasRelatedWork W1557621914 @default.
- W1988126189 hasRelatedWork W1988126189 @default.
- W1988126189 hasRelatedWork W1989852590 @default.
- W1988126189 hasRelatedWork W2080803812 @default.
- W1988126189 hasRelatedWork W2170240601 @default.
- W1988126189 hasRelatedWork W2594626140 @default.
- W1988126189 hasRelatedWork W2753457547 @default.
- W1988126189 hasRelatedWork W3136031961 @default.
- W1988126189 hasRelatedWork W3161778279 @default.
- W1988126189 hasRelatedWork W4285087335 @default.
- W1988126189 hasVolume "32" @default.
- W1988126189 isParatext "false" @default.
- W1988126189 isRetracted "false" @default.
- W1988126189 magId "1988126189" @default.
- W1988126189 workType "article" @default.