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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988139709> ?p ?o ?g. }

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• W1988139709 abstract "We describe the discovery of small molecule benzazepine derivatives as agonists of human peroxisome proliferator-activated receptor δ (PPARδ) that displayed excellent selectivity over the PPARα and PPARγ subtypes. Compound 8 displayed good PK in the rat and efficacy in upregulation of pyruvate dehydrogenase kinase, isozyme 4 (PDK4) mRNA in human primary myotubes, a biomarker for increased fatty acid oxidation." @default.
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• W1988139709 date "2011-01-01" @default.
• W1988139709 modified "2023-09-27" @default.
• W1988139709 title "Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists" @default.
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• W1988139709 doi "https://doi.org/10.1016/j.bmcl.2010.10.083" @default.
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