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- W1988146345 abstract "The nicotine metabolite cotinine is widely used to assess the extent of tobacco use in smokers, and secondhand smoke exposure in non-smokers. The ratio of another nicotine metabolite, trans-3'-hydroxycotinine, to cotinine in biofluids is highly correlated with the rate of nicotine metabolism, which is catalyzed mainly by cytochrome P450 2A6 (CYP2A6). Consequently, this nicotine metabolite ratio is being used to phenotype individuals for CYP2A6 activity and to individualize pharmacotherapies for tobacco addiction. In this paper we describe a highly sensitive liquid chromatography-tandem mass spectrometry method for determination of the nicotine metabolites cotinine and trans-3'-hydroxycotinine in human plasma, urine, and saliva. Lower limits of quantitation range from 0.02 to 0.1ng/mL. The extraction procedure is straightforward and suitable for large-scale studies. The method has been applied to several thousand biofluid samples for pharmacogenetic studies and for studies of exposure to low levels of secondhand smoke. Concentrations of both metabolites in urine of non-smokers with different levels of secondhand smoke exposure are presented." @default.
- W1988146345 created "2016-06-24" @default.
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- W1988146345 date "2011-02-01" @default.
- W1988146345 modified "2023-10-06" @default.
- W1988146345 title "Determination of the nicotine metabolites cotinine and trans-3′-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography–tandem mass spectrometry: Biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity" @default.
- W1988146345 cites W1515542254 @default.
- W1988146345 cites W1791887780 @default.
- W1988146345 cites W1867313983 @default.
- W1988146345 cites W1882229593 @default.
- W1988146345 cites W1897950719 @default.
- W1988146345 cites W1920493917 @default.
- W1988146345 cites W1966593979 @default.
- W1988146345 cites W1969176202 @default.
- W1988146345 cites W1969940333 @default.
- W1988146345 cites W1970427955 @default.
- W1988146345 cites W1971579639 @default.
- W1988146345 cites W1977706673 @default.
- W1988146345 cites W1984300319 @default.
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- W1988146345 cites W1995599815 @default.
- W1988146345 cites W2000607733 @default.
- W1988146345 cites W2004271508 @default.
- W1988146345 cites W2011700094 @default.
- W1988146345 cites W2014003991 @default.
- W1988146345 cites W2015234747 @default.
- W1988146345 cites W2017574768 @default.
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- W1988146345 doi "https://doi.org/10.1016/j.jchromb.2010.12.012" @default.
- W1988146345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3050598" @default.
- W1988146345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21208832" @default.
- W1988146345 hasPublicationYear "2011" @default.
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