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- W1988148915 abstract "The electroencephalographic effects of two intravenous sedative/hypnotic drugs, propofol and thiopental, were studied at three stable blood concentrations in 52 normal healthy volunteers. The higher concentration resulted in unresponsiveness (lack of response to auditory/tactile stimuli) in all subjects. This report describes the strong frontal-central rhythms apparent in this state using a quantitative description of oscillatory systems underlying the rhythm. These rhythms occur when sedative drug concentrations are greater than those producing the well-described increase in broadband β-power associated with many sedative drugs. Propofol induces rhythms in the α-range, while thiopental produces rhythms in the β-range. Quasistationary for a period of about 1 h, these rhythms exceed the baseline α-rhythm in power. By their resonant nature, these propofol-induced rhythms are analogous to ‘the classic α-rhythm’, but quantitative characteristics of the underlying oscillatory systems are different. Baseline properties of the oscillatory system underlying the initial resting α-rhythm recover completely as drug concentration decays to negligible values." @default.
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- W1988148915 date "2004-01-01" @default.
- W1988148915 modified "2023-09-25" @default.
- W1988148915 title "Propofol-Induced Alpha Rhythm" @default.
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- W1988148915 doi "https://doi.org/10.1159/000079981" @default.
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