FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988156767> ?p ?o ?g. }

• W1988156767 endingPage "372" @default.
• W1988156767 startingPage "357" @default.
• W1988156767 abstract "Vaccine approaches against AIDS have focused on inducing cellular immune responses, since many studies revealed the role of T cell responses in the control of human immunodeficiency virus or simian immunodeficiency virus (SIV) infections. The experimental infection of rhesus macaques with SIV or chimeric SHIV is routinely used as a model for AIDS. In such models, DNA immunization is a tool to elicit specific T cell responses and to study their protective efficacy. DNA immunogenicity in primates depends on parameters such as level of antigen expression, choice of the antigen among SIV proteins, use of fusion proteins, route of immunization, and addition of adjuvants. Recent results suggest that priming with DNA and boosting with attenuated recombinant viral vectors, each expressing corresponding SIV antigens, leads to improved specific immunity and, in some cases, affords protection against pathogenic challenge. After preclinical evaluations, DNA has entered clinical trials for a therapeutic or prophylactic gene-based AIDS vaccine. Les nouvelles approches vaccinales contre le SIDA visent principalement à induire une réponse immunitaire cellulaire. En effet, de nombreuses études ont montré le rôle des lymphocytes T dans le contrôle de l'infection par les virus de l'immunodéficience humaine (VIH) et simienne (VIS). L'infection expérimentale du macaque rhesus par le virus VIS ou par un virus chimérique VIH/VIS est couramment utilisée comme modèle du SIDA humain. L'immunisation à base d'ADN ou vaccination génétique apparaı̂t comme un outil de choix pour l'induction de réponses T dans ces modèles. Ce nouveau mode d'immunisation a été beaucoup amélioré au cours des dix dernières années. Plus récemment, de nombreuses études suggèrent que la combinaison entre vaccins à base d'ADN et vecteurs viraux atténués exprimant des antigènes communs permet d'améliorer de manière significative les réponses immunitaires spécifiques. Après de nombreuses évaluations précliniques chez l'animal, ces vaccins, aussi bien prophylactiques que thérapeutiques, sont entrés dans des phases d'essais cliniques chez l'homme." @default.
• W1988156767 created "2016-06-24" @default.
• W1988156767 creator A5001130819 @default.
• W1988156767 creator A5033281553 @default.
• W1988156767 date "2003-10-01" @default.
• W1988156767 modified "2023-09-27" @default.
• W1988156767 title "New gene-based approaches for an AIDS vaccine" @default.
• W1988156767 cites W1492241828 @default.
• W1988156767 cites W1586476245 @default.
• W1988156767 cites W1596667011 @default.
• W1988156767 cites W1605749243 @default.
• W1988156767 cites W16961449 @default.
• W1988156767 cites W1826616136 @default.
• W1988156767 cites W1918610311 @default.
• W1988156767 cites W1919528337 @default.
• W1988156767 cites W1963640298 @default.
• W1988156767 cites W1965243467 @default.
• W1988156767 cites W1965569618 @default.
• W1988156767 cites W1967965262 @default.
• W1988156767 cites W1974018802 @default.
• W1988156767 cites W1974787656 @default.
• W1988156767 cites W1988106168 @default.
• W1988156767 cites W1991165973 @default.
• W1988156767 cites W1991410878 @default.
• W1988156767 cites W1991799944 @default.
• W1988156767 cites W2025481552 @default.
• W1988156767 cites W2037343680 @default.
• W1988156767 cites W2048053576 @default.
• W1988156767 cites W2051108441 @default.
• W1988156767 cites W2055632588 @default.
• W1988156767 cites W2070426326 @default.
• W1988156767 cites W2077116918 @default.
• W1988156767 cites W2077348914 @default.
• W1988156767 cites W2081825634 @default.
• W1988156767 cites W2085919513 @default.
• W1988156767 cites W2089478501 @default.
• W1988156767 cites W2097755672 @default.
• W1988156767 cites W2098781795 @default.
• W1988156767 cites W2101581475 @default.
• W1988156767 cites W2103461151 @default.
• W1988156767 cites W2108961890 @default.
• W1988156767 cites W2109434501 @default.
• W1988156767 cites W2111929893 @default.
• W1988156767 cites W2117522423 @default.
• W1988156767 cites W2120106310 @default.
• W1988156767 cites W2122904806 @default.
• W1988156767 cites W2124969212 @default.
• W1988156767 cites W2129166390 @default.
• W1988156767 cites W2129907648 @default.
• W1988156767 cites W2131974188 @default.
• W1988156767 cites W2135073267 @default.
• W1988156767 cites W2141028568 @default.
• W1988156767 cites W2145031719 @default.
• W1988156767 cites W2146706646 @default.
• W1988156767 cites W2147851449 @default.
• W1988156767 cites W2149762607 @default.
• W1988156767 cites W2151181830 @default.
• W1988156767 cites W2154374820 @default.
• W1988156767 cites W2158798674 @default.
• W1988156767 cites W2329203517 @default.
• W1988156767 cites W2408794999 @default.
• W1988156767 cites W1506827869 @default.
• W1988156767 doi "https://doi.org/10.1016/s0147-9571(03)00020-1" @default.
• W1988156767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12818622" @default.
• W1988156767 hasPublicationYear "2003" @default.
• W1988156767 type Work @default.
• W1988156767 sameAs 1988156767 @default.
• W1988156767 citedByCount "4" @default.
• W1988156767 crossrefType "journal-article" @default.
• W1988156767 hasAuthorship W1988156767A5001130819 @default.
• W1988156767 hasAuthorship W1988156767A5033281553 @default.
• W1988156767 hasConcept C147483822 @default.
• W1988156767 hasConcept C159047783 @default.
• W1988156767 hasConcept C167508917 @default.
• W1988156767 hasConcept C203014093 @default.
• W1988156767 hasConcept C2522874641 @default.
• W1988156767 hasConcept C2777995582 @default.
• W1988156767 hasConcept C2779341262 @default.
• W1988156767 hasConcept C2779690655 @default.
• W1988156767 hasConcept C2780727368 @default.
• W1988156767 hasConcept C2780801004 @default.
• W1988156767 hasConcept C2780868878 @default.
• W1988156767 hasConcept C3017875465 @default.
• W1988156767 hasConcept C86803240 @default.
• W1988156767 hasConcept C8891405 @default.
• W1988156767 hasConceptScore W1988156767C147483822 @default.
• W1988156767 hasConceptScore W1988156767C159047783 @default.
• W1988156767 hasConceptScore W1988156767C167508917 @default.
• W1988156767 hasConceptScore W1988156767C203014093 @default.
• W1988156767 hasConceptScore W1988156767C2522874641 @default.
• W1988156767 hasConceptScore W1988156767C2777995582 @default.
• W1988156767 hasConceptScore W1988156767C2779341262 @default.
• W1988156767 hasConceptScore W1988156767C2779690655 @default.
• W1988156767 hasConceptScore W1988156767C2780727368 @default.
• W1988156767 hasConceptScore W1988156767C2780801004 @default.
• W1988156767 hasConceptScore W1988156767C2780868878 @default.
• W1988156767 hasConceptScore W1988156767C3017875465 @default.
• W1988156767 hasConceptScore W1988156767C86803240 @default.

• next