Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988156822> ?p ?o ?g. }
- W1988156822 endingPage "e26502" @default.
- W1988156822 startingPage "e26502" @default.
- W1988156822 abstract "Using DNA microarrays, we generated both mRNA and miRNA expression data from 6 non-small cell lung cancer (NSCLC) tissues and their matching normal control from adjacent tissues to identify potential miRNA markers for diagnostics. We demonstrated that hsa-miR-96 is significantly and consistently up-regulated in all 6 NSCLCs. We validated this result in an independent set of 35 paired tumors and their adjacent normal tissues, as well as their sera that are collected before surgical resection or chemotherapy, and the results suggested that hsa-miR-96 may play an important role in NSCLC development and has great potential to be used as a noninvasive marker for diagnosing NSCLC. We predicted potential miRNA target mRNAs based on different methods (TargetScan and miRanda). Further classification of miRNA regulated genes based on their relationship with miRNAs revealed that hsa-miR-96 and certain other miRNAs tend to down-regulate their target mRNAs in NSCLC development, which have expression levels permissive to direct interaction between miRNAs and their target mRNAs. In addition, we identified a significant correlation of miRNA regulation with genes coincide with high density of CpG islands, which suggests that miRNA may represent a primary regulatory mechanism governing basic cellular functions and cell differentiations, and such mechanism may be complementary to DNA methylation in repressing or activating gene expression." @default.
- W1988156822 created "2016-06-24" @default.
- W1988156822 creator A5001829389 @default.
- W1988156822 creator A5018962441 @default.
- W1988156822 creator A5019775208 @default.
- W1988156822 creator A5036314491 @default.
- W1988156822 creator A5045819980 @default.
- W1988156822 creator A5052295445 @default.
- W1988156822 creator A5063088523 @default.
- W1988156822 creator A5073922441 @default.
- W1988156822 creator A5080403233 @default.
- W1988156822 date "2011-10-27" @default.
- W1988156822 modified "2023-09-27" @default.
- W1988156822 title "An Integrated Analysis of miRNA and mRNA Expressions in Non-Small Cell Lung Cancers" @default.
- W1988156822 cites W1771753901 @default.
- W1988156822 cites W1967841068 @default.
- W1988156822 cites W1974740818 @default.
- W1988156822 cites W1975003033 @default.
- W1988156822 cites W1980269624 @default.
- W1988156822 cites W1982503072 @default.
- W1988156822 cites W1985931135 @default.
- W1988156822 cites W1988089341 @default.
- W1988156822 cites W1989376396 @default.
- W1988156822 cites W1993312546 @default.
- W1988156822 cites W1993799748 @default.
- W1988156822 cites W1997041221 @default.
- W1988156822 cites W1998449659 @default.
- W1988156822 cites W1998516698 @default.
- W1988156822 cites W1998995840 @default.
- W1988156822 cites W2006797972 @default.
- W1988156822 cites W2006998565 @default.
- W1988156822 cites W2013344284 @default.
- W1988156822 cites W2014064723 @default.
- W1988156822 cites W2026322564 @default.
- W1988156822 cites W2026570544 @default.
- W1988156822 cites W2027444951 @default.
- W1988156822 cites W2030341656 @default.
- W1988156822 cites W2033188250 @default.
- W1988156822 cites W2038090381 @default.
- W1988156822 cites W2038766179 @default.
- W1988156822 cites W2050066317 @default.
- W1988156822 cites W2050869737 @default.
- W1988156822 cites W2057638710 @default.
- W1988156822 cites W2062890651 @default.
- W1988156822 cites W2063557805 @default.
- W1988156822 cites W2066976755 @default.
- W1988156822 cites W2077393126 @default.
- W1988156822 cites W2082010591 @default.
- W1988156822 cites W2083381199 @default.
- W1988156822 cites W2087065324 @default.
- W1988156822 cites W2089570814 @default.
- W1988156822 cites W2091934374 @default.
- W1988156822 cites W2091982059 @default.
- W1988156822 cites W2093593077 @default.
- W1988156822 cites W2101410152 @default.
- W1988156822 cites W2102326716 @default.
- W1988156822 cites W2107277218 @default.
- W1988156822 cites W2109136664 @default.
- W1988156822 cites W2109431382 @default.
- W1988156822 cites W2109769677 @default.
- W1988156822 cites W2120456037 @default.
- W1988156822 cites W2121417064 @default.
- W1988156822 cites W2130979840 @default.
- W1988156822 cites W2133098474 @default.
- W1988156822 cites W2133968430 @default.
- W1988156822 cites W2135613885 @default.
- W1988156822 cites W2137505881 @default.
- W1988156822 cites W2141171810 @default.
- W1988156822 cites W2146642335 @default.
- W1988156822 cites W2148942441 @default.
- W1988156822 cites W2151922790 @default.
- W1988156822 cites W2154719999 @default.
- W1988156822 cites W2163199119 @default.
- W1988156822 cites W2164687768 @default.
- W1988156822 cites W2165463056 @default.
- W1988156822 cites W2169562832 @default.
- W1988156822 cites W2171836441 @default.
- W1988156822 cites W2359189303 @default.
- W1988156822 cites W2407172097 @default.
- W1988156822 cites W2410784319 @default.
- W1988156822 cites W2769219274 @default.
- W1988156822 doi "https://doi.org/10.1371/journal.pone.0026502" @default.
- W1988156822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3203153" @default.
- W1988156822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22046296" @default.
- W1988156822 hasPublicationYear "2011" @default.
- W1988156822 type Work @default.
- W1988156822 sameAs 1988156822 @default.
- W1988156822 citedByCount "70" @default.
- W1988156822 countsByYear W19881568222012 @default.
- W1988156822 countsByYear W19881568222013 @default.
- W1988156822 countsByYear W19881568222014 @default.
- W1988156822 countsByYear W19881568222015 @default.
- W1988156822 countsByYear W19881568222016 @default.
- W1988156822 countsByYear W19881568222017 @default.
- W1988156822 countsByYear W19881568222018 @default.
- W1988156822 countsByYear W19881568222019 @default.
- W1988156822 countsByYear W19881568222020 @default.
- W1988156822 countsByYear W19881568222021 @default.