FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988158045> ?p ?o ?g. }

• W1988158045 endingPage "1027" @default.
• W1988158045 startingPage "1015" @default.
• W1988158045 abstract "The in vitro dispersion of salmeterol xinafoate (SX) alone and four SX (2.5%)-coarse lactose (CL) mixtures containing 0%, 5%, 10% and 20% micronised lactose (ML) was monitored during 18-month storage at 33%, 55% and 75% relative humidity (RH) using a twin stage impinger. The surface moisture was monitored over 2 months by thermo gravimetric analysis. The morphology was determined by scanning electron microscopy. An aerosizer was used to compare the agglomerate strengths of formulations before and after storage at 75% RH. Upon storage, no significant difference occurred in fine particle fraction (FPF) of any formulation at 33% and 55% RH. Within 8 weeks, the FPF of mixture containing 20% ML (M20F) significantly decreased from 11.3% to 7.7% at 75% RH (p = 0.008) and to 4.9% at 95% RH (p = 0.001). The calculated capillary forces were greater for ML-ML contact than other particle interactions and the propensity of ML-ML contacts was higher in M20F. The agglomerate strength of M20F significantly increased after storage. The study concluded that the critical factors for decreased dispersion of SX formulations were RH of 75% or greater and the presence of high concentrations of ML due to capillary forces and/or solid bridge formation of ML leading to increased agglomerate strength." @default.
• W1988158045 created "2016-06-24" @default.
• W1988158045 creator A5001201301 @default.
• W1988158045 creator A5012646235 @default.
• W1988158045 creator A5064119734 @default.
• W1988158045 creator A5070623493 @default.
• W1988158045 date "2009-03-01" @default.
• W1988158045 modified "2023-10-17" @default.
• W1988158045 title "Influence of Storage Relative Humidity on the Dispersion of Salmeterol Xinafoate Powders for Inhalation" @default.
• W1988158045 cites W129419657 @default.
• W1988158045 cites W1965712863 @default.
• W1988158045 cites W1965732698 @default.
• W1988158045 cites W1970491868 @default.
• W1988158045 cites W1973989535 @default.
• W1988158045 cites W1977712203 @default.
• W1988158045 cites W1981996336 @default.
• W1988158045 cites W1985558994 @default.
• W1988158045 cites W1993160844 @default.
• W1988158045 cites W2005316212 @default.
• W1988158045 cites W2008133194 @default.
• W1988158045 cites W2010531987 @default.
• W1988158045 cites W2019019222 @default.
• W1988158045 cites W2024086418 @default.
• W1988158045 cites W2025303383 @default.
• W1988158045 cites W2036648843 @default.
• W1988158045 cites W2053923955 @default.
• W1988158045 cites W2061655935 @default.
• W1988158045 cites W2063544369 @default.
• W1988158045 cites W2075952461 @default.
• W1988158045 cites W2084194047 @default.
• W1988158045 cites W2084257990 @default.
• W1988158045 cites W2086068280 @default.
• W1988158045 cites W2086224770 @default.
• W1988158045 cites W2091766231 @default.
• W1988158045 cites W2091860466 @default.
• W1988158045 cites W2121258813 @default.
• W1988158045 cites W2171291356 @default.
• W1988158045 doi "https://doi.org/10.1002/jps.21500" @default.
• W1988158045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18661537" @default.
• W1988158045 hasPublicationYear "2009" @default.
• W1988158045 type Work @default.
• W1988158045 sameAs 1988158045 @default.
• W1988158045 citedByCount "30" @default.
• W1988158045 countsByYear W19881580452012 @default.
• W1988158045 countsByYear W19881580452013 @default.
• W1988158045 countsByYear W19881580452014 @default.
• W1988158045 countsByYear W19881580452016 @default.
• W1988158045 countsByYear W19881580452017 @default.
• W1988158045 countsByYear W19881580452018 @default.
• W1988158045 countsByYear W19881580452019 @default.
• W1988158045 countsByYear W19881580452020 @default.
• W1988158045 countsByYear W19881580452021 @default.
• W1988158045 crossrefType "journal-article" @default.
• W1988158045 hasAuthorship W1988158045A5001201301 @default.
• W1988158045 hasAuthorship W1988158045A5012646235 @default.
• W1988158045 hasAuthorship W1988158045A5064119734 @default.
• W1988158045 hasAuthorship W1988158045A5070623493 @default.
• W1988158045 hasConcept C113196181 @default.
• W1988158045 hasConcept C120665830 @default.
• W1988158045 hasConcept C121332964 @default.
• W1988158045 hasConcept C129955480 @default.
• W1988158045 hasConcept C140793950 @default.
• W1988158045 hasConcept C147789679 @default.
• W1988158045 hasConcept C153294291 @default.
• W1988158045 hasConcept C158960510 @default.
• W1988158045 hasConcept C159985019 @default.
• W1988158045 hasConcept C176864760 @default.
• W1988158045 hasConcept C177562468 @default.
• W1988158045 hasConcept C178790620 @default.
• W1988158045 hasConcept C185592680 @default.
• W1988158045 hasConcept C187530423 @default.
• W1988158045 hasConcept C192562407 @default.
• W1988158045 hasConcept C196806460 @default.
• W1988158045 hasConcept C2778724459 @default.
• W1988158045 hasConcept C31903555 @default.
• W1988158045 hasConcept C43617362 @default.
• W1988158045 hasConcept C86803240 @default.
• W1988158045 hasConcept C96278889 @default.
• W1988158045 hasConceptScore W1988158045C113196181 @default.
• W1988158045 hasConceptScore W1988158045C120665830 @default.
• W1988158045 hasConceptScore W1988158045C121332964 @default.
• W1988158045 hasConceptScore W1988158045C129955480 @default.
• W1988158045 hasConceptScore W1988158045C140793950 @default.
• W1988158045 hasConceptScore W1988158045C147789679 @default.
• W1988158045 hasConceptScore W1988158045C153294291 @default.
• W1988158045 hasConceptScore W1988158045C158960510 @default.
• W1988158045 hasConceptScore W1988158045C159985019 @default.
• W1988158045 hasConceptScore W1988158045C176864760 @default.
• W1988158045 hasConceptScore W1988158045C177562468 @default.
• W1988158045 hasConceptScore W1988158045C178790620 @default.
• W1988158045 hasConceptScore W1988158045C185592680 @default.
• W1988158045 hasConceptScore W1988158045C187530423 @default.
• W1988158045 hasConceptScore W1988158045C192562407 @default.
• W1988158045 hasConceptScore W1988158045C196806460 @default.
• W1988158045 hasConceptScore W1988158045C2778724459 @default.
• W1988158045 hasConceptScore W1988158045C31903555 @default.
• W1988158045 hasConceptScore W1988158045C43617362 @default.
• W1988158045 hasConceptScore W1988158045C86803240 @default.

• next