Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988166665> ?p ?o ?g. }
- W1988166665 endingPage "2375" @default.
- W1988166665 startingPage "2364" @default.
- W1988166665 abstract "The solution conformations of tetrameric and hexameric cyclopeptides containing alternating L-proline and 6-aminopicolinic acid subunits strongly depend on solvent polarity. Whereas in polar solvents, such as d6-DMSO, both peptides prefer on average symmetric conformations with converging NH groups, in less polar chloroform intramolecular hydrogen bonds to the peptide NH groups stabilize other, and in the case of the hexapeptide, non-symmetrical conformations. Independent of the solvent, both peptides interact with anions via their NH groups but whereas anion binding requires a cleavage of the intramolecular hydrogen bonds accompanied by a conformational reorganization in chloroform, in polar solvents the peptides are already well preorganized for anion complexation. Complex formation between anions and the cyclic hexapeptide was even detected in highly competitive D2O/CD3OD or H2O/CH3CN mixtures, which was attributed to the special sandwich-type structure of the complexes formed. Stabilizing these 2:1 aggregates by covalently linking two cyclopeptide rings together affords ditopic receptors with a high anion affinity in protic solvents. Complex stability depends on the structure of the linker with which the two receptor moieties are connected and even more potent anion receptors were obtained by a dynamic combinatorial optimization of this linking unit." @default.
- W1988166665 created "2016-06-24" @default.
- W1988166665 creator A5021502893 @default.
- W1988166665 creator A5026960327 @default.
- W1988166665 creator A5036368076 @default.
- W1988166665 creator A5037346929 @default.
- W1988166665 creator A5070963235 @default.
- W1988166665 creator A5086109930 @default.
- W1988166665 date "2005-05-15" @default.
- W1988166665 modified "2023-10-03" @default.
- W1988166665 title "Optimization of the binding properties of a synthetic anion receptor using rational and combinatorial strategies" @default.
- W1988166665 cites W1489417672 @default.
- W1988166665 cites W1524661399 @default.
- W1988166665 cites W1648880131 @default.
- W1988166665 cites W1974445988 @default.
- W1988166665 cites W1975003486 @default.
- W1988166665 cites W1975816406 @default.
- W1988166665 cites W1977742319 @default.
- W1988166665 cites W1981132589 @default.
- W1988166665 cites W1986098447 @default.
- W1988166665 cites W1990840444 @default.
- W1988166665 cites W2002316662 @default.
- W1988166665 cites W2003184231 @default.
- W1988166665 cites W2008822792 @default.
- W1988166665 cites W2010376644 @default.
- W1988166665 cites W2012194915 @default.
- W1988166665 cites W2012778134 @default.
- W1988166665 cites W2014704069 @default.
- W1988166665 cites W2020441569 @default.
- W1988166665 cites W2021002810 @default.
- W1988166665 cites W2022853264 @default.
- W1988166665 cites W2023111753 @default.
- W1988166665 cites W2030298654 @default.
- W1988166665 cites W2031044187 @default.
- W1988166665 cites W2033344693 @default.
- W1988166665 cites W2034478162 @default.
- W1988166665 cites W2041007921 @default.
- W1988166665 cites W2044059101 @default.
- W1988166665 cites W2054590453 @default.
- W1988166665 cites W2054805144 @default.
- W1988166665 cites W2057834109 @default.
- W1988166665 cites W2059082118 @default.
- W1988166665 cites W2059322172 @default.
- W1988166665 cites W2061564498 @default.
- W1988166665 cites W2063211012 @default.
- W1988166665 cites W2068304210 @default.
- W1988166665 cites W2068370484 @default.
- W1988166665 cites W2070466213 @default.
- W1988166665 cites W2071360944 @default.
- W1988166665 cites W2076747645 @default.
- W1988166665 cites W2081377598 @default.
- W1988166665 cites W2085683540 @default.
- W1988166665 cites W2086781270 @default.
- W1988166665 cites W2093150174 @default.
- W1988166665 cites W2093511784 @default.
- W1988166665 cites W2103680519 @default.
- W1988166665 cites W2109466768 @default.
- W1988166665 cites W2116073261 @default.
- W1988166665 cites W2119295002 @default.
- W1988166665 cites W2132682133 @default.
- W1988166665 cites W2140815785 @default.
- W1988166665 cites W2148066840 @default.
- W1988166665 cites W2156876917 @default.
- W1988166665 cites W2157377686 @default.
- W1988166665 cites W2162746364 @default.
- W1988166665 cites W2171109575 @default.
- W1988166665 cites W594144343 @default.
- W1988166665 cites W2144777184 @default.
- W1988166665 doi "https://doi.org/10.1016/j.bios.2004.01.035" @default.
- W1988166665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15797340" @default.
- W1988166665 hasPublicationYear "2005" @default.
- W1988166665 type Work @default.
- W1988166665 sameAs 1988166665 @default.
- W1988166665 citedByCount "35" @default.
- W1988166665 countsByYear W19881666652012 @default.
- W1988166665 countsByYear W19881666652013 @default.
- W1988166665 countsByYear W19881666652014 @default.
- W1988166665 countsByYear W19881666652015 @default.
- W1988166665 countsByYear W19881666652020 @default.
- W1988166665 crossrefType "journal-article" @default.
- W1988166665 hasAuthorship W1988166665A5021502893 @default.
- W1988166665 hasAuthorship W1988166665A5026960327 @default.
- W1988166665 hasAuthorship W1988166665A5036368076 @default.
- W1988166665 hasAuthorship W1988166665A5037346929 @default.
- W1988166665 hasAuthorship W1988166665A5070963235 @default.
- W1988166665 hasAuthorship W1988166665A5086109930 @default.
- W1988166665 hasBestOaLocation W19881666652 @default.
- W1988166665 hasConcept C111919701 @default.
- W1988166665 hasConcept C112887158 @default.
- W1988166665 hasConcept C178790620 @default.
- W1988166665 hasConcept C185592680 @default.
- W1988166665 hasConcept C21951064 @default.
- W1988166665 hasConcept C2779281246 @default.
- W1988166665 hasConcept C2780471494 @default.
- W1988166665 hasConcept C2780557392 @default.
- W1988166665 hasConcept C2781144210 @default.
- W1988166665 hasConcept C32909587 @default.
- W1988166665 hasConcept C41008148 @default.