FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988172324> ?p ?o ?g. }

• W1988172324 endingPage "499" @default.
• W1988172324 startingPage "483" @default.
• W1988172324 abstract "Localized intracellular Ca(2+) elevations known as puffs and sparks arise from the cooperative activity of inositol 1,4,5-trisphosphate receptor Ca(2+) channels (IP(3)Rs) and ryanodine receptor Ca(2+) channels (RyRs) clustered at Ca(2+) release sites on the surface of the endoplasmic reticulum or sarcoplasmic reticulum. When Markov chain models of these intracellular Ca(2+)-regulated Ca(2+) channels are coupled via a mathematical representation of a Ca(2+) microdomain, simulated Ca(2+) release sites may exhibit the phenomenon of stochastic Ca(2+) excitability reminiscent of Ca(2+) puffs and sparks where channels open and close in a concerted fashion. To clarify the role of Ca(2+) inactivation of IP(3)Rs and RyRs in the dynamics of puffs and sparks, we formulate and analyze Markov chain models of Ca(2+) release sites composed of 10-40 three-state intracellular Ca(2+) channels that are inactivated as well as activated by Ca(2+). We study how the statistics of simulated puffs and sparks depend on the kinetics and dissociation constant of Ca(2+) inactivation and find that puffs and sparks are often less sensitive to variations in the number of channels at release sites and strength of coupling via local [Ca(2+)] when the average fraction of inactivated channels is significant. Interestingly, we observe that the single channel kinetics of Ca(2+) inactivation influences the thermodynamic entropy production rate of Markov chain models of puffs and sparks. While excessively fast Ca(2+) inactivation can preclude puffs and sparks, moderately fast Ca(2+) inactivation often leads to time-irreversible puffs and sparks whose termination is facilitated by the recruitment of inactivated channels throughout the duration of the puff/spark event. On the other hand, Ca(2+) inactivation may be an important negative feedback mechanism even when its time constant is much greater than the duration of puffs and sparks. In fact, slow Ca(2+) inactivation can lead to release sites with a substantial fraction of inactivated channels that exhibit puffs and sparks that are nearly time-reversible and terminate without additional recruitment of inactivated channels." @default.
• W1988172324 created "2016-06-24" @default.
• W1988172324 creator A5077859814 @default.
• W1988172324 creator A5087903861 @default.
• W1988172324 date "2008-08-01" @default.
• W1988172324 modified "2023-10-16" @default.
• W1988172324 title "Calcium-dependent inactivation and the dynamics of calcium puffs and sparks" @default.
• W1988172324 cites W1263387749 @default.
• W1988172324 cites W1595525782 @default.
• W1988172324 cites W1661761832 @default.
• W1988172324 cites W1670760110 @default.
• W1988172324 cites W1857532475 @default.
• W1988172324 cites W1963851776 @default.
• W1988172324 cites W1968004732 @default.
• W1988172324 cites W1973352820 @default.
• W1988172324 cites W1977533719 @default.
• W1988172324 cites W1979207635 @default.
• W1988172324 cites W1983730633 @default.
• W1988172324 cites W1991002565 @default.
• W1988172324 cites W1997778815 @default.
• W1988172324 cites W1999335128 @default.
• W1988172324 cites W2001541852 @default.
• W1988172324 cites W2009482199 @default.
• W1988172324 cites W2011038097 @default.
• W1988172324 cites W2012751980 @default.
• W1988172324 cites W2012859616 @default.
• W1988172324 cites W2013560023 @default.
• W1988172324 cites W2014668324 @default.
• W1988172324 cites W2016414732 @default.
• W1988172324 cites W2016789956 @default.
• W1988172324 cites W2021647551 @default.
• W1988172324 cites W2028114248 @default.
• W1988172324 cites W2032403667 @default.
• W1988172324 cites W2039600625 @default.
• W1988172324 cites W2042321087 @default.
• W1988172324 cites W2045106617 @default.
• W1988172324 cites W2050668851 @default.
• W1988172324 cites W2050824263 @default.
• W1988172324 cites W2054225000 @default.
• W1988172324 cites W2056222025 @default.
• W1988172324 cites W2057665893 @default.
• W1988172324 cites W2062157267 @default.
• W1988172324 cites W2062202483 @default.
• W1988172324 cites W2080804424 @default.
• W1988172324 cites W2081172975 @default.
• W1988172324 cites W2085898654 @default.
• W1988172324 cites W2089936541 @default.
• W1988172324 cites W2091387127 @default.
• W1988172324 cites W2091811857 @default.
• W1988172324 cites W2099430463 @default.
• W1988172324 cites W2104554319 @default.
• W1988172324 cites W2113183554 @default.
• W1988172324 cites W2138958648 @default.
• W1988172324 cites W2140313595 @default.
• W1988172324 cites W2150991652 @default.
• W1988172324 cites W2151839418 @default.
• W1988172324 cites W2152958680 @default.
• W1988172324 cites W2161496609 @default.
• W1988172324 cites W2163736419 @default.
• W1988172324 cites W2166278741 @default.
• W1988172324 cites W2170006809 @default.
• W1988172324 cites W2170688389 @default.
• W1988172324 cites W2171437709 @default.
• W1988172324 cites W2263821109 @default.
• W1988172324 doi "https://doi.org/10.1016/j.jtbi.2008.03.026" @default.
• W1988172324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18486154" @default.
• W1988172324 hasPublicationYear "2008" @default.
• W1988172324 type Work @default.
• W1988172324 sameAs 1988172324 @default.
• W1988172324 citedByCount "27" @default.
• W1988172324 countsByYear W19881723242012 @default.
• W1988172324 countsByYear W19881723242014 @default.
• W1988172324 countsByYear W19881723242015 @default.
• W1988172324 countsByYear W19881723242016 @default.
• W1988172324 countsByYear W19881723242022 @default.
• W1988172324 countsByYear W19881723242023 @default.
• W1988172324 crossrefType "journal-article" @default.
• W1988172324 hasAuthorship W1988172324A5077859814 @default.
• W1988172324 hasAuthorship W1988172324A5087903861 @default.
• W1988172324 hasConcept C113217602 @default.
• W1988172324 hasConcept C121332964 @default.
• W1988172324 hasConcept C12554922 @default.
• W1988172324 hasConcept C148898269 @default.
• W1988172324 hasConcept C158617107 @default.
• W1988172324 hasConcept C178790620 @default.
• W1988172324 hasConcept C185592680 @default.
• W1988172324 hasConcept C201571599 @default.
• W1988172324 hasConcept C519063684 @default.
• W1988172324 hasConcept C55493867 @default.
• W1988172324 hasConcept C62520636 @default.
• W1988172324 hasConcept C79879829 @default.
• W1988172324 hasConcept C86803240 @default.
• W1988172324 hasConceptScore W1988172324C113217602 @default.
• W1988172324 hasConceptScore W1988172324C121332964 @default.
• W1988172324 hasConceptScore W1988172324C12554922 @default.
• W1988172324 hasConceptScore W1988172324C148898269 @default.
• W1988172324 hasConceptScore W1988172324C158617107 @default.
• W1988172324 hasConceptScore W1988172324C178790620 @default.

• next