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• W1988179976 abstract "The carboxyl terminal tail domains of the heavy and middle molecular weight mammalian neurofilament (NF) proteins regulate inter-NF spacing and formation of organized networks. The C-terminal region of the larger of the two lamprey NF subunits (NF-180) resembles these mammalian proteins in that it consists of a proximal glutamate-rich region and a distal region containing multiple phosphorylation sites. To investigate the role of these two sidearm domains in the organization of lamprey NFs, we generated plasmids lacking the glutamate-rich domain, the domain containing multiple phosphorylation sites, or both, and examined the impact of the resultant mutant proteins on the endogenous NF network in differentiated NB21/d1 neuroblastoma cells. We present evidence that, like mammalian NFs, the glutamate-rich region of NF-180 sidearm plays a critical role in NF architecture." @default.
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• W1988179976 date "2008-09-01" @default.
• W1988179976 modified "2023-09-25" @default.
• W1988179976 title "The glutamate-rich region of the larger lamprey neurofilament sidearm is essential for proper neurofilament architecture" @default.
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• W1988179976 doi "https://doi.org/10.1016/j.brainres.2008.07.050" @default.
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