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- W1988202421 endingPage "e98569" @default.
- W1988202421 startingPage "e98569" @default.
- W1988202421 abstract "Within the Flaviviridae, the recently designated genus Pegivirus has expanded greatly due to new discoveries in bats, horses, and rodents. Here we report the discovery and characterization of three simian pegiviruses (SPgV) that resemble human pegivirus (HPgV) and infect red colobus monkeys (Procolobus tephrosceles), red-tailed guenons (Cercopithecus ascanius) and an olive baboon (Papio anubis). We have designated these viruses SPgVkrc, SPgVkrtg and SPgVkbab, reflecting their host species' common names, which include reference to their location of origin in Kibale National Park, Uganda. SPgVkrc and SPgVkrtg were detected in 47% (28/60) of red colobus and 42% (5/12) red-tailed guenons, respectively, while SPgVkbab infection was observed in 1 of 23 olive baboons tested. Infections were not associated with any apparent disease, despite the generally high viral loads observed for each variant. These viruses were monophyletic and equally divergent from HPgV and pegiviruses previously identified in chimpanzees (SPgVcpz). Overall, the high degree of conservation of genetic features among the novel SPgVs, HPgV and SPgVcpz suggests conservation of function among these closely related viruses. Our study describes the first primate pegiviruses detected in Old World monkeys, expanding the known genetic diversity and host range of pegiviruses and providing insight into the natural history of this genus." @default.
- W1988202421 created "2016-06-24" @default.
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- W1988202421 date "2014-06-11" @default.
- W1988202421 modified "2023-10-13" @default.
- W1988202421 title "Discovery and Characterization of Distinct Simian Pegiviruses in Three Wild African Old World Monkey Species" @default.
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- W1988202421 doi "https://doi.org/10.1371/journal.pone.0098569" @default.
- W1988202421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4053331" @default.
- W1988202421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24918769" @default.