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- W1988203492 abstract "Abstract Methoxychlor was fed to a group of fourteen healthy 6-month-old dogs, at a dose of 2.5 gm/kg body weight/day, mixed in the feed. These animals were killed, one at a time, at various time intervals during the next 12 weeks. Tissue from the small intestinal mucosa was rapidly removed, properly processed and examined by electron microscopy. A progressive degeneration of the mitochondria marked in the early stages by matrical swelling and disruption of the cristae was the most pronounced finding. Later, myelin bodies appeared while the swollen mitochondria became vacuolated and their cristae were gone. One animal was taken off the methoxychlor diet after 12 weeks, fed the control diet for 3 weeks and then killed. The mitochondria of the intestinal epithelium were not so involved as those of the dogs fed methoxychlor for several weeks. A possible mechanism of pathogenesis is presented in the Discussion." @default.
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- W1988203492 date "1968-04-01" @default.
- W1988203492 modified "2023-09-26" @default.
- W1988203492 title "Progressive ultrastructural changes in the mucosal epithelium of the small intestine of beagle dogs fed methoxychlor" @default.
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- W1988203492 doi "https://doi.org/10.1016/0014-4800(68)90019-1" @default.
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