FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988204042> ?p ?o ?g. }

• W1988204042 endingPage "56" @default.
• W1988204042 startingPage "50" @default.
• W1988204042 abstract "An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted from the degradation of phenolic acids. However, whether PA has anti-fibrotic functions is unknown. In this study, the effects of PA on the transforming growth factor-β1 (TGF-β1)-mediated epithelial–mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. PA treatment resulted in a reduction of EMT in A549 cells with a decrease in vimentin and HMGB, an increase of E-cadherin and RAGE, a reduction of HLF-1 proliferation with a decrease of fibroblast growth factor 2 (FGF-2) and platelet-derived growth factor (PDGF). Apoptosis of AT I was attenuated with an increase of RAGE. PA ameliorated BLM-induced pulmonary fibrosis in rats with a reduction of histopathological scores and collagen deposition, and a lower FGF-2, PDGF, α-smooth muscle actin (α-SMA) and HMGB1 expression, whereas higher RAGE was found in BLM-instilled lungs. Through the decrease of HGMB1 and the regulation of RAGE, PA reversed the EMT, inhibited HLF-1 proliferation as well as reduced apoptosis in AT I, and prevented pulmonary fibrosis in vivo. Collectively, our results demonstrate that PA prevents experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway." @default.
• W1988204042 created "2016-06-24" @default.
• W1988204042 creator A5052982162 @default.
• W1988204042 creator A5060636354 @default.
• W1988204042 creator A5066599847 @default.
• W1988204042 creator A5071725354 @default.
• W1988204042 creator A5075455117 @default.
• W1988204042 date "2015-02-01" @default.
• W1988204042 modified "2023-10-18" @default.
• W1988204042 title "Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway" @default.
• W1988204042 cites W1523427575 @default.
• W1988204042 cites W1687290736 @default.
• W1988204042 cites W1969833190 @default.
• W1988204042 cites W1979937536 @default.
• W1988204042 cites W1993559550 @default.
• W1988204042 cites W2004266769 @default.
• W1988204042 cites W2005640704 @default.
• W1988204042 cites W2015992961 @default.
• W1988204042 cites W2018636086 @default.
• W1988204042 cites W2018809578 @default.
• W1988204042 cites W2032860933 @default.
• W1988204042 cites W2045067067 @default.
• W1988204042 cites W2054379331 @default.
• W1988204042 cites W2075400164 @default.
• W1988204042 cites W2085781412 @default.
• W1988204042 cites W2099285472 @default.
• W1988204042 cites W2104778949 @default.
• W1988204042 cites W2111223419 @default.
• W1988204042 cites W2115141581 @default.
• W1988204042 cites W2136005561 @default.
• W1988204042 cites W2136831137 @default.
• W1988204042 cites W2137569729 @default.
• W1988204042 cites W2157693596 @default.
• W1988204042 cites W2161568523 @default.
• W1988204042 cites W2166550136 @default.
• W1988204042 cites W2167383172 @default.
• W1988204042 doi "https://doi.org/10.1016/j.taap.2015.01.001" @default.
• W1988204042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25582705" @default.
• W1988204042 hasPublicationYear "2015" @default.
• W1988204042 type Work @default.
• W1988204042 sameAs 1988204042 @default.
• W1988204042 citedByCount "38" @default.
• W1988204042 countsByYear W19882040422015 @default.
• W1988204042 countsByYear W19882040422016 @default.
• W1988204042 countsByYear W19882040422017 @default.
• W1988204042 countsByYear W19882040422018 @default.
• W1988204042 countsByYear W19882040422019 @default.
• W1988204042 countsByYear W19882040422020 @default.
• W1988204042 countsByYear W19882040422021 @default.
• W1988204042 countsByYear W19882040422022 @default.
• W1988204042 countsByYear W19882040422023 @default.
• W1988204042 crossrefType "journal-article" @default.
• W1988204042 hasAuthorship W1988204042A5052982162 @default.
• W1988204042 hasAuthorship W1988204042A5060636354 @default.
• W1988204042 hasAuthorship W1988204042A5066599847 @default.
• W1988204042 hasAuthorship W1988204042A5071725354 @default.
• W1988204042 hasAuthorship W1988204042A5075455117 @default.
• W1988204042 hasConcept C104317684 @default.
• W1988204042 hasConcept C118131993 @default.
• W1988204042 hasConcept C126322002 @default.
• W1988204042 hasConcept C127561419 @default.
• W1988204042 hasConcept C134018914 @default.
• W1988204042 hasConcept C142724271 @default.
• W1988204042 hasConcept C147447768 @default.
• W1988204042 hasConcept C147990577 @default.
• W1988204042 hasConcept C169760540 @default.
• W1988204042 hasConcept C170493617 @default.
• W1988204042 hasConcept C180361614 @default.
• W1988204042 hasConcept C185592680 @default.
• W1988204042 hasConcept C190283241 @default.
• W1988204042 hasConcept C203014093 @default.
• W1988204042 hasConcept C204232928 @default.
• W1988204042 hasConcept C2775960820 @default.
• W1988204042 hasConcept C2776232574 @default.
• W1988204042 hasConcept C2776694085 @default.
• W1988204042 hasConcept C2778857457 @default.
• W1988204042 hasConcept C2780545709 @default.
• W1988204042 hasConcept C2780559512 @default.
• W1988204042 hasConcept C2781244666 @default.
• W1988204042 hasConcept C502942594 @default.
• W1988204042 hasConcept C55493867 @default.
• W1988204042 hasConcept C71924100 @default.
• W1988204042 hasConcept C76419328 @default.
• W1988204042 hasConcept C86803240 @default.
• W1988204042 hasConceptScore W1988204042C104317684 @default.
• W1988204042 hasConceptScore W1988204042C118131993 @default.
• W1988204042 hasConceptScore W1988204042C126322002 @default.
• W1988204042 hasConceptScore W1988204042C127561419 @default.
• W1988204042 hasConceptScore W1988204042C134018914 @default.
• W1988204042 hasConceptScore W1988204042C142724271 @default.
• W1988204042 hasConceptScore W1988204042C147447768 @default.
• W1988204042 hasConceptScore W1988204042C147990577 @default.
• W1988204042 hasConceptScore W1988204042C169760540 @default.
• W1988204042 hasConceptScore W1988204042C170493617 @default.
• W1988204042 hasConceptScore W1988204042C180361614 @default.
• W1988204042 hasConceptScore W1988204042C185592680 @default.
• W1988204042 hasConceptScore W1988204042C190283241 @default.
• W1988204042 hasConceptScore W1988204042C203014093 @default.

• next