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- W1988204057 endingPage "33025" @default.
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- W1988204057 abstract "Hormone regulation of ion transport in the kidney tubules is essential for fluid and electrolyte homeostasis in vertebrates. A large body of evidence has suggested that transporters and channels exist in multiprotein regulatory complexes; however, relatively little is known about the composition of these complexes or their assembly. The epithelial sodium channel (ENaC) in particular is tightly regulated by the salt-regulatory hormone aldosterone, which acts at least in part by increasing expression of the serine-threonine kinase SGK1. Here we show that aldosterone induces the formation of a 1.0-1.2-MDa plasma membrane complex, which includes ENaC, SGK1, and the ENaC inhibitor Nedd4-2, a key target of SGK1. We further show that this complex contains the PDZ domain-containing protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3). CNK3 physically interacts with ENaC, Nedd4-2, and SGK1; enhances the interactions among them; and stimulates ENaC function in a PDZ domain-dependent, aldosterone-induced manner. These results strongly suggest that CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis." @default.
- W1988204057 created "2016-06-24" @default.
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- W1988204057 creator A5086532458 @default.
- W1988204057 date "2012-09-01" @default.
- W1988204057 modified "2023-09-26" @default.
- W1988204057 title "Scaffold Protein Connector Enhancer of Kinase Suppressor of Ras Isoform 3 (CNK3) Coordinates Assembly of a Multiprotein Epithelial Sodium Channel (ENaC)-regulatory Complex" @default.
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- W1988204057 doi "https://doi.org/10.1074/jbc.m112.389148" @default.
- W1988204057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3463358" @default.
- W1988204057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22851176" @default.
- W1988204057 hasPublicationYear "2012" @default.
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