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- W1988213568 abstract "Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10). The structures of the new compounds were determined by analysis of their spectroscopic data. Among the isolated compounds, 5'-formylglabridin (5), (2R,3R)-3,4',7-trihydroxy-3'-prenylflavane (7), echinatin, (3R)-2',3',7-trihydroxy-4'-methoxyisoflavan, kanzonol X, kanzonol W, shinpterocarpin, licoflavanone A, glabrol, shinflavanone, gancaonin L, and glabrone all exhibited significant PPAR-gamma ligand-binding activity. The activity of these compounds at a sample concentration of 10microg/mL was three times more potent than that of 0.5microM troglitazone." @default.
- W1988213568 created "2016-06-24" @default.
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- W1988213568 date "2010-01-01" @default.
- W1988213568 modified "2023-09-23" @default.
- W1988213568 title "Phenolics from Glycyrrhiza glabra roots and their PPAR-γ ligand-binding activity" @default.
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- W1988213568 doi "https://doi.org/10.1016/j.bmc.2009.11.027" @default.
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