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- W1988219427 abstract "To study the repair capacity of fertilized mouse eggs for X-ray damage induced in sperm and mature oocytes, the potentiating effects of 3 well-known repair inhibitors, arabinofuranosyl cytosine (ara-C), 3-aminobenzamide (3AB) and caffeine, on the frequency of induced chromosome aberrations were examined in eggs fertilized with X-irradiated sperm or in eggs irradiated with X-rays at the mature oocyte stage immediately before fertilization. Gametic treatment, fertilization and embryo culture were carried out in vitro. Ara-C treatment was done only in the pre-DNA replication period, while treatment with 3AB and caffeine was continuous from fertilization to the first-cleavage metaphase. The induction of chromosome aberrations by exposing sperm ot oocytes to X-rays was remarkably potentiated by post-treatment incubation in the presence of each of the 3 inhibitors. This result indicates the possibility that X-ray damage induced in sperm or oocytes is reparable in the fertilized eggs and that various types of repair processes are involved." @default.
- W1988219427 created "2016-06-24" @default.
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- W1988219427 creator A5047991911 @default.
- W1988219427 date "1989-01-01" @default.
- W1988219427 modified "2023-09-30" @default.
- W1988219427 title "Repair capacity of fertilized mouse eggs for X-ray damage induced in sperm and mature oocytes" @default.
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- W1988219427 doi "https://doi.org/10.1016/0027-5107(89)90042-0" @default.
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