FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988219667> ?p ?o ?g. }

• W1988219667 endingPage "7032" @default.
• W1988219667 startingPage "7023" @default.
• W1988219667 abstract "Abstract Purpose: To establish the pharmacokinetic and pharmacodynamic profile of the heat shock protein 90 (HSP90) inhibitor 17-allylamino, 17-demethoxygeldanamycin (17-AAG) in ovarian cancer xenograft models. Experimental Design: The effects of 17-AAG on growth inhibition and the expression of pharmacodynamic biomarkers c-RAF-1, CDK4, and HSP70 were studied in human ovarian cancer cell lines A2780 and CH1. Corresponding experiments were conducted with established tumor xenografts. The variability and specificity of pharmacodynamic markers in human peripheral blood lymphocytes (PBL) were studied. Results: The IC50 values of 17-AAG in A2780 and CH1 cells were 18.3 nmol/L (SD, 2.3) and 410.1 nmol/L (SD, 9.4), respectively. Pharmacodynamic changes indicative of HSP90 inhibition were demonstrable at greater than or equal the IC50 concentration in both cell lines. Xenograft experiments confirmed tumor growth inhibition in vivo. Peak concentrations of 17-AAG achieved in A2780 and CH1 tumors were 15.6 and 16.5 μmol/L, respectively, and there was no significant difference between day 1 and 11 pharmacokinetic profiles. Reversible changes in pharmacodynamic biomarkers were shown in tumor and murine PBLs in both xenograft models. Expression of pharmacodynamic markers varied between human PBLs from different human volunteers but not within the same individual. Pharmacodynamic biomarker changes consistent with HSP90 inhibition were shown in human PBLs exposed ex vivo to 17-AAG but not to selected cytotoxic drugs. Conclusion: Pharmacokinetic-pharmacodynamic relationships were established for 17-AAG. This information formed the basis of a pharmacokinetic-pharmacodynamic-driven phase I trial." @default.
• W1988219667 created "2016-06-24" @default.
• W1988219667 creator A5003965204 @default.
• W1988219667 creator A5032401979 @default.
• W1988219667 creator A5041062763 @default.
• W1988219667 creator A5053304892 @default.
• W1988219667 creator A5058014829 @default.
• W1988219667 creator A5072764615 @default.
• W1988219667 creator A5081946554 @default.
• W1988219667 creator A5091648628 @default.
• W1988219667 date "2005-10-01" @default.
• W1988219667 modified "2023-10-07" @default.
• W1988219667 title "Pharmacokinetic-Pharmacodynamic Relationships for the Heat Shock Protein 90 Molecular Chaperone Inhibitor 17-Allylamino, 17-Demethoxygeldanamycin in Human Ovarian Cancer Xenograft Models" @default.
• W1988219667 cites W1515542254 @default.
• W1988219667 cites W1596822567 @default.
• W1988219667 cites W1964826325 @default.
• W1988219667 cites W1965849506 @default.
• W1988219667 cites W1970392870 @default.
• W1988219667 cites W1979313821 @default.
• W1988219667 cites W1984370974 @default.
• W1988219667 cites W1988692190 @default.
• W1988219667 cites W1999307044 @default.
• W1988219667 cites W2000929246 @default.
• W1988219667 cites W2000980666 @default.
• W1988219667 cites W2003003988 @default.
• W1988219667 cites W2009899654 @default.
• W1988219667 cites W2014790326 @default.
• W1988219667 cites W2020178430 @default.
• W1988219667 cites W2021534705 @default.
• W1988219667 cites W2029789274 @default.
• W1988219667 cites W2034269086 @default.
• W1988219667 cites W2037356096 @default.
• W1988219667 cites W2047782251 @default.
• W1988219667 cites W2049546697 @default.
• W1988219667 cites W2054022422 @default.
• W1988219667 cites W2074579328 @default.
• W1988219667 cites W2082390299 @default.
• W1988219667 cites W2084582184 @default.
• W1988219667 cites W2086185470 @default.
• W1988219667 cites W2088938008 @default.
• W1988219667 cites W2096955693 @default.
• W1988219667 cites W2099302625 @default.
• W1988219667 cites W2100611890 @default.
• W1988219667 cites W2108230631 @default.
• W1988219667 cites W2111187586 @default.
• W1988219667 cites W2112133866 @default.
• W1988219667 cites W2112417555 @default.
• W1988219667 cites W2117487251 @default.
• W1988219667 cites W2123056940 @default.
• W1988219667 cites W2128373232 @default.
• W1988219667 cites W2133635118 @default.
• W1988219667 cites W2136276051 @default.
• W1988219667 cites W2136395938 @default.
• W1988219667 cites W2137819605 @default.
• W1988219667 cites W2139306838 @default.
• W1988219667 cites W2144818233 @default.
• W1988219667 cites W2148488190 @default.
• W1988219667 cites W2154995637 @default.
• W1988219667 cites W2158341833 @default.
• W1988219667 cites W2162107265 @default.
• W1988219667 cites W2173081403 @default.
• W1988219667 cites W2257690327 @default.
• W1988219667 cites W2479044294 @default.
• W1988219667 doi "https://doi.org/10.1158/1078-0432.ccr-05-0518" @default.
• W1988219667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16203796" @default.
• W1988219667 hasPublicationYear "2005" @default.
• W1988219667 type Work @default.
• W1988219667 sameAs 1988219667 @default.
• W1988219667 citedByCount "153" @default.
• W1988219667 countsByYear W19882196672012 @default.
• W1988219667 countsByYear W19882196672013 @default.
• W1988219667 countsByYear W19882196672014 @default.
• W1988219667 countsByYear W19882196672015 @default.
• W1988219667 countsByYear W19882196672016 @default.
• W1988219667 countsByYear W19882196672017 @default.
• W1988219667 countsByYear W19882196672018 @default.
• W1988219667 countsByYear W19882196672019 @default.
• W1988219667 countsByYear W19882196672020 @default.
• W1988219667 countsByYear W19882196672021 @default.
• W1988219667 countsByYear W19882196672022 @default.
• W1988219667 crossrefType "journal-article" @default.
• W1988219667 hasAuthorship W1988219667A5003965204 @default.
• W1988219667 hasAuthorship W1988219667A5032401979 @default.
• W1988219667 hasAuthorship W1988219667A5041062763 @default.
• W1988219667 hasAuthorship W1988219667A5053304892 @default.
• W1988219667 hasAuthorship W1988219667A5058014829 @default.
• W1988219667 hasAuthorship W1988219667A5072764615 @default.
• W1988219667 hasAuthorship W1988219667A5081946554 @default.
• W1988219667 hasAuthorship W1988219667A5091648628 @default.
• W1988219667 hasBestOaLocation W19882196671 @default.
• W1988219667 hasConcept C104317684 @default.
• W1988219667 hasConcept C111113717 @default.
• W1988219667 hasConcept C112705442 @default.
• W1988219667 hasConcept C121608353 @default.
• W1988219667 hasConcept C126322002 @default.
• W1988219667 hasConcept C150903083 @default.
• W1988219667 hasConcept C205260736 @default.
• W1988219667 hasConcept C207001950 @default.

• next