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• W1988220653 abstract "Objective: The aims of this study were to review studies on the molecular genetics of child temperament and prospectively analyze infant temperament as a function of the interaction between infant and mother: 5-HTT, DRD4, and MAO-A functional polymorphisms and the mother's emotional state. Method: A prospective study of 317 newborns and their mothers was performed. Infant temperament and the mother's anxiety and confidence in caregiving were evaluated at 8 and 32 weeks after childbirth using the Mother and Baby Scale. The mother's emotional state was evaluated using the Edinburgh Postpartum Depression Scale and the State-Trait Anxiety Inventory. These variables were correlated with 5-HTTLPR and Stin2 variants in the 5-HTT gene and the DRD4 variable number tandem repeats Exon 3 and MAO-A variable number tandem repeats genotypes of both the infants and their mothers. Results: The irritability scores of infants with the 5-HTTLPR s allele showed a linear relationship with their mothers' anxiety of caregiving at 8 (p = .011) and 32 weeks (p = .001), whereas the irritability of infants carrying the HTTLPR ll genotype was independent of their mothers' anxiety. Conclusions: The review of the literature in this field and the results of this study support that the 5-HTTLPR polymorphism moderates the influence of the mother's anxiety on infant irritability." @default.
• W1988220653 created "2016-06-24" @default.
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• W1988220653 date "2010-09-01" @default.
• W1988220653 modified "2023-10-10" @default.
• W1988220653 title "Gene-Environment Interaction of Child Temperament" @default.
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• W1988220653 doi "https://doi.org/10.1097/dbp.0b013e3181ee4072" @default.
• W1988220653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20729761" @default.
• W1988220653 hasPublicationYear "2010" @default.
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