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• W1988222024 abstract "High frequency oscillations (HFOs) can be recorded with depth electrodes in focal epilepsy patients. They occur during seizures and interictally and seem important in seizure genesis. We investigated whether interictal and ictal HFOs occur in the same regions and how they relate to epileptiform spikes.In 25 patients, spikes, ripples (80-250 Hz) and fast ripples (FR: 250-500 Hz) and their co-occurrences were marked during interictal slow wave sleep (5-10 min), during 10 pre-ictal seconds and 5s following seizure onset. We compared occurrence and spatial distribution between these periods.HFOs and spikes increased from interictal to ictal periods: the percentage of time occupied by ripples increased from 2.3% to 6.5%, FR from 0.2% to 0.8%, spikes from 1.1% to 4.8%. HFOs increased from interictal to pre-ictal periods in contrast to spikes. Spikes were in different channels in the interictal, pre-ictal and ictal periods whereas HFOs largely remained in the same channels.HFOs remain confined to the same, possibly epileptogenic, area, during interictal and ictal periods, while spikes are more widespread during seizures than interictally.Ictal and interictal HFOs represent the same (epileptogenic) area and are probably similar phenomena." @default.
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• W1988222024 date "2011-04-01" @default.
• W1988222024 modified "2023-10-18" @default.
• W1988222024 title "Ictal and interictal high frequency oscillations in patients with focal epilepsy" @default.
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• W1988222024 doi "https://doi.org/10.1016/j.clinph.2010.09.021" @default.
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