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• W1988224726 abstract "Emulsified systems are widely used for topical delivery with the aim of optimizing cutaneous absorption and offering a pleasant sensory. They also may provide a protection of the active molecule against oxidation and/or degradation. The oil phase of o/w emulsions may consist of liquid crystalline structures, especially lamellar structures which are similar to those found in the stratum corneum lipids. In the present work, o/w emulsions containing liquid crystals of mixed cetyl alcohol and Polysorbate 60 were developed for topical delivery of vitamin C, a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. In addition to the well-documented lipid supplementation of the stratum corneum, the liquid crystal emulsions provide a significant chemical stabilization of vitamin C against its degradation. Emulsions were characterized by X-ray diffraction, polarized optical microscopy, and transmission electron microscopy. The stability of vitamin C in the formulations was evaluated upon storage in different conditions of temperature. The emulsions contain a complex colloidal structure, consisting of lamellar liquid crystalline (Lα) and crystalline lamellar gel (Lβ) phases, that provide a very efficient protection of vitamin C against its degradation." @default.
• W1988224726 created "2016-06-24" @default.
• W1988224726 creator A5004043513 @default.
• W1988224726 creator A5040818748 @default.
• W1988224726 date "1996-03-01" @default.
• W1988224726 modified "2023-10-18" @default.
• W1988224726 title "Topical vitamin C in aging" @default.
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• W1988224726 doi "https://doi.org/10.1016/0738-081x(95)00158-c" @default.
• W1988224726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8860861" @default.
• W1988224726 hasPublicationYear "1996" @default.
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