FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988227536> ?p ?o ?g. }

• W1988227536 endingPage "221" @default.
• W1988227536 startingPage "212" @default.
• W1988227536 abstract "Abstract: Melanocytes arise from the neural crest, migrate to the skin, and can be detected in the basal layer of the epidermis in skin biopsies of human fetuses as early as 11 weeks gestational age. During post-natal life, melanocytes reside at the basal layer of the epidermis, but the ligands to which they attach are unknown. Laminin-5 is a component of anchoring filaments of the lamina lucida of the epidermal basement membrane. In this report we show that human melanocytes adhere to purified laminin-5 to a level comparable with normal human keratinocytes. Blocking antibodies to the 165 kDa subunit of laminin-5 significantly inhibited fetal and neonatal melanocyte attachment to the surface of saltsplit skin, which exposes laminin-5 on its surface, suggesting that laminin-5 is a ligand for melanocyte attachment to the basement membrane in vivo. Western blotting of concentrated culture supernatant of fetal and neonatal melanocytes with anti-laminin-5 antibodies demonstrated a single immunoreactive band of the expected size of laminin-5. In contrast, 3 human metastatic melanoma cell lines did not produce laminin-5. Immunofluorescence microscopy with antibodies to each of the three chains of laminin-5 confirmed the presence of laminin-5 in a peri-cellular distribution around melanocytes, but not melanoma cells. Our results suggest that laminin-5 may be a ligand for normal human melanocytes in the basement membrane, and that loss of laminin-5 production by melanoma cells may be a marker for malignant transformation." @default.
• W1988227536 created "2016-06-24" @default.
• W1988227536 creator A5035817460 @default.
• W1988227536 creator A5051726920 @default.
• W1988227536 creator A5054891354 @default.
• W1988227536 creator A5084471701 @default.
• W1988227536 creator A5085366413 @default.
• W1988227536 date "1999-06-01" @default.
• W1988227536 modified "2023-09-29" @default.
• W1988227536 title "Melanocytes adhere to and synthesize laminin-5 in vitro" @default.
• W1988227536 cites W1575158045 @default.
• W1988227536 cites W1888764902 @default.
• W1988227536 cites W1975750661 @default.
• W1988227536 cites W1984264867 @default.
• W1988227536 cites W1994124209 @default.
• W1988227536 cites W2006570971 @default.
• W1988227536 cites W2020137812 @default.
• W1988227536 cites W2023658543 @default.
• W1988227536 cites W2030635244 @default.
• W1988227536 cites W2034159932 @default.
• W1988227536 cites W2039739172 @default.
• W1988227536 cites W2043976294 @default.
• W1988227536 cites W2046770269 @default.
• W1988227536 cites W2059287983 @default.
• W1988227536 cites W2075965099 @default.
• W1988227536 cites W2076062389 @default.
• W1988227536 cites W2077406309 @default.
• W1988227536 cites W2082091722 @default.
• W1988227536 cites W2093884083 @default.
• W1988227536 cites W2094463466 @default.
• W1988227536 cites W2100837269 @default.
• W1988227536 cites W2102193002 @default.
• W1988227536 cites W2115146277 @default.
• W1988227536 cites W2117250276 @default.
• W1988227536 cites W2133996152 @default.
• W1988227536 cites W2138316626 @default.
• W1988227536 cites W2148399778 @default.
• W1988227536 cites W2155649238 @default.
• W1988227536 cites W2167970431 @default.
• W1988227536 cites W2258601739 @default.
• W1988227536 cites W4250204739 @default.
• W1988227536 cites W4255690169 @default.
• W1988227536 cites W53647604 @default.
• W1988227536 doi "https://doi.org/10.1111/j.1600-0625.1999.tb00373.x" @default.
• W1988227536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10389639" @default.
• W1988227536 hasPublicationYear "1999" @default.
• W1988227536 type Work @default.
• W1988227536 sameAs 1988227536 @default.
• W1988227536 citedByCount "14" @default.
• W1988227536 countsByYear W19882275362014 @default.
• W1988227536 countsByYear W19882275362017 @default.
• W1988227536 countsByYear W19882275362019 @default.
• W1988227536 countsByYear W19882275362020 @default.
• W1988227536 countsByYear W19882275362021 @default.
• W1988227536 crossrefType "journal-article" @default.
• W1988227536 hasAuthorship W1988227536A5035817460 @default.
• W1988227536 hasAuthorship W1988227536A5051726920 @default.
• W1988227536 hasAuthorship W1988227536A5054891354 @default.
• W1988227536 hasAuthorship W1988227536A5084471701 @default.
• W1988227536 hasAuthorship W1988227536A5085366413 @default.
• W1988227536 hasBestOaLocation W19882275361 @default.
• W1988227536 hasConcept C105702510 @default.
• W1988227536 hasConcept C142724271 @default.
• W1988227536 hasConcept C189165786 @default.
• W1988227536 hasConcept C202751555 @default.
• W1988227536 hasConcept C2776193487 @default.
• W1988227536 hasConcept C2776458125 @default.
• W1988227536 hasConcept C2777074287 @default.
• W1988227536 hasConcept C2777459323 @default.
• W1988227536 hasConcept C2777658100 @default.
• W1988227536 hasConcept C2779333224 @default.
• W1988227536 hasConcept C2779769559 @default.
• W1988227536 hasConcept C2779814568 @default.
• W1988227536 hasConcept C3060791 @default.
• W1988227536 hasConcept C44843598 @default.
• W1988227536 hasConcept C502942594 @default.
• W1988227536 hasConcept C54355233 @default.
• W1988227536 hasConcept C55493867 @default.
• W1988227536 hasConcept C71924100 @default.
• W1988227536 hasConcept C86803240 @default.
• W1988227536 hasConcept C87555872 @default.
• W1988227536 hasConcept C95444343 @default.
• W1988227536 hasConceptScore W1988227536C105702510 @default.
• W1988227536 hasConceptScore W1988227536C142724271 @default.
• W1988227536 hasConceptScore W1988227536C189165786 @default.
• W1988227536 hasConceptScore W1988227536C202751555 @default.
• W1988227536 hasConceptScore W1988227536C2776193487 @default.
• W1988227536 hasConceptScore W1988227536C2776458125 @default.
• W1988227536 hasConceptScore W1988227536C2777074287 @default.
• W1988227536 hasConceptScore W1988227536C2777459323 @default.
• W1988227536 hasConceptScore W1988227536C2777658100 @default.
• W1988227536 hasConceptScore W1988227536C2779333224 @default.
• W1988227536 hasConceptScore W1988227536C2779769559 @default.
• W1988227536 hasConceptScore W1988227536C2779814568 @default.
• W1988227536 hasConceptScore W1988227536C3060791 @default.
• W1988227536 hasConceptScore W1988227536C44843598 @default.
• W1988227536 hasConceptScore W1988227536C502942594 @default.
• W1988227536 hasConceptScore W1988227536C54355233 @default.

• next