FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988227755> ?p ?o ?g. }

• W1988227755 endingPage "1454" @default.
• W1988227755 startingPage "1448" @default.
• W1988227755 abstract "In Brief Background Cardiac transplantation is the last resort for patients with end-stage heart failure. Ischemia-reperfusion (IR) injury is a major issue in cardiac transplantation. Inflammatory processes play a major role in myocardial IR injury. However, the cellular and molecular immune mechanisms of myocardial IR injury remain elusive. Methods Hearts of C57BL/6 mice were flushed and stored in cold Bretschneider solution for 8 hr and then transplanted into syngeneic recipient. The involvement of high-mobility group box 1 (Hmgb1) and interleukin (IL)-17A was assessed in functional assays by neutralizing Hmgb1 or IL-17A. Results IL-17A was elevated after myocardial IR injury in cardiac transplantation. IL-17A was predominantly produced by γδT cells rather than CD4+ or CD8+ T cells infiltrated into the cardiac isografts. Neutralizing antibody against IL-17A or γδTCR attenuated cardiomyocyte apoptosis and neutrophil recruitment. Furthermore, a neutralizing IL-23p19 antibody decreased the level of IL-17A and neutrophil infiltration. Importantly, IL-23 and IL-17A were reduced after inhibition of macrophages and could not be induced in TLR4-/- mice after IR injury. Meanwhile, Hmgb1 increased after IR injury and the Hmgb1 inhibitor glycyrrhizin markedly reduced the production of IL-23 and IL-17A and ameliorated myocardial IR injury. Conclusion The Hmgb1-TLR4-IL-23-IL-17A axis contributes to cardiomyocyte apoptosis, neutrophil accumulation and IR injury in cardiac transplantation. Supplemental digital content is available in the article." @default.
• W1988227755 created "2016-06-24" @default.
• W1988227755 creator A5004309272 @default.
• W1988227755 creator A5008801443 @default.
• W1988227755 creator A5012278873 @default.
• W1988227755 creator A5016580028 @default.
• W1988227755 creator A5023071584 @default.
• W1988227755 creator A5074077900 @default.
• W1988227755 date "2013-06-27" @default.
• W1988227755 modified "2023-09-22" @default.
• W1988227755 title "Hmgb1-TLR4-IL-23-IL-17A Axis Promote Ischemia-Reperfusion Injury in a Cardiac Transplantation Model" @default.
• W1988227755 cites W1506391594 @default.
• W1988227755 cites W1585461212 @default.
• W1988227755 cites W1655860314 @default.
• W1988227755 cites W1969305254 @default.
• W1988227755 cites W1984804536 @default.
• W1988227755 cites W1987767880 @default.
• W1988227755 cites W1989358807 @default.
• W1988227755 cites W2004266769 @default.
• W1988227755 cites W2005251993 @default.
• W1988227755 cites W2005552681 @default.
• W1988227755 cites W2006249161 @default.
• W1988227755 cites W2008359016 @default.
• W1988227755 cites W2020371427 @default.
• W1988227755 cites W2023749167 @default.
• W1988227755 cites W2025575974 @default.
• W1988227755 cites W2037985527 @default.
• W1988227755 cites W2046388159 @default.
• W1988227755 cites W2049372707 @default.
• W1988227755 cites W2054472394 @default.
• W1988227755 cites W2060527543 @default.
• W1988227755 cites W2064316640 @default.
• W1988227755 cites W2066362593 @default.
• W1988227755 cites W2068533658 @default.
• W1988227755 cites W2071464503 @default.
• W1988227755 cites W2081521873 @default.
• W1988227755 cites W2087983368 @default.
• W1988227755 cites W2093897672 @default.
• W1988227755 cites W2098915990 @default.
• W1988227755 cites W2104614292 @default.
• W1988227755 cites W2106949373 @default.
• W1988227755 cites W2107235439 @default.
• W1988227755 cites W2114041096 @default.
• W1988227755 cites W2116415854 @default.
• W1988227755 cites W2122206763 @default.
• W1988227755 cites W2125937547 @default.
• W1988227755 cites W2135981165 @default.
• W1988227755 cites W2136784260 @default.
• W1988227755 cites W2164450453 @default.
• W1988227755 cites W62313570 @default.
• W1988227755 doi "https://doi.org/10.1097/tp.0b013e318293b7e1" @default.
• W1988227755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23677049" @default.
• W1988227755 hasPublicationYear "2013" @default.
• W1988227755 type Work @default.
• W1988227755 sameAs 1988227755 @default.
• W1988227755 citedByCount "70" @default.
• W1988227755 countsByYear W19882277552013 @default.
• W1988227755 countsByYear W19882277552014 @default.
• W1988227755 countsByYear W19882277552015 @default.
• W1988227755 countsByYear W19882277552016 @default.
• W1988227755 countsByYear W19882277552017 @default.
• W1988227755 countsByYear W19882277552018 @default.
• W1988227755 countsByYear W19882277552019 @default.
• W1988227755 countsByYear W19882277552020 @default.
• W1988227755 countsByYear W19882277552021 @default.
• W1988227755 countsByYear W19882277552022 @default.
• W1988227755 countsByYear W19882277552023 @default.
• W1988227755 crossrefType "journal-article" @default.
• W1988227755 hasAuthorship W1988227755A5004309272 @default.
• W1988227755 hasAuthorship W1988227755A5008801443 @default.
• W1988227755 hasAuthorship W1988227755A5012278873 @default.
• W1988227755 hasAuthorship W1988227755A5016580028 @default.
• W1988227755 hasAuthorship W1988227755A5023071584 @default.
• W1988227755 hasAuthorship W1988227755A5074077900 @default.
• W1988227755 hasBestOaLocation W19882277551 @default.
• W1988227755 hasConcept C126322002 @default.
• W1988227755 hasConcept C164027704 @default.
• W1988227755 hasConcept C185592680 @default.
• W1988227755 hasConcept C190283241 @default.
• W1988227755 hasConcept C203014093 @default.
• W1988227755 hasConcept C2776070231 @default.
• W1988227755 hasConcept C2776914184 @default.
• W1988227755 hasConcept C2780114680 @default.
• W1988227755 hasConcept C2780545709 @default.
• W1988227755 hasConcept C2911091166 @default.
• W1988227755 hasConcept C541997718 @default.
• W1988227755 hasConcept C55493867 @default.
• W1988227755 hasConcept C71924100 @default.
• W1988227755 hasConcept C98274493 @default.
• W1988227755 hasConceptScore W1988227755C126322002 @default.
• W1988227755 hasConceptScore W1988227755C164027704 @default.
• W1988227755 hasConceptScore W1988227755C185592680 @default.
• W1988227755 hasConceptScore W1988227755C190283241 @default.
• W1988227755 hasConceptScore W1988227755C203014093 @default.
• W1988227755 hasConceptScore W1988227755C2776070231 @default.
• W1988227755 hasConceptScore W1988227755C2776914184 @default.
• W1988227755 hasConceptScore W1988227755C2780114680 @default.
• W1988227755 hasConceptScore W1988227755C2780545709 @default.

• next