FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988232005> ?p ?o ?g. }

• W1988232005 endingPage "352" @default.
• W1988232005 startingPage "347" @default.
• W1988232005 abstract "A transmembrane glycoprotein recently identified on some tumor cells, extracellular matrix metalloproteinase inducer (EMMPRIN), has been shown to induce metalloproteinase (MMP) production by peritumor fibroblasts (PTF). We examined biopsy specimens of normal human oral mucosa and oral squamous cell carcinoma (SCC) for expression of EMMPRIN. In normal mucosa, EMMPRIN was expressed at the cell membrane throughout the epithelium with a slight enhancement along the basal cell layer. In oral SCC, EMMPRIN was expressed at the cell membrane throughout the entire lesion. Immunofluorescence microscopy localized EMMPRIN to the cell membrane in a highly invasive oral SCC cell line in agreement with our in vivo observations. Function-blocking antibodies to EMMPRIN significantly inhibited oral SCC cell migration on tenascin-C (TN-C) and fibronectin as well as invasion through a reconstituted basement membrane (RBM). We previously showed that soluble factors from SCC cells and PTF are required for deposition of a TN-C matrix. To determine whether EMMPRIN may modulate the release or expression of these soluble factors, we again used function-blocking antibodies. Antibodies to EMMPRIN completely inhibited the organization of TN-C matrices and partially reduced the deposition of FN matrices by oral SCC cell /PTF co-cultures. In addition, antibodies to EMMPRIN perturbed the expression of MMP-2. Moreover, antibodies to MMP-2 perturbed oral SCC cell invasion of an RBM by approx. 75%. Our results demonstrate that EMMPRIN is highly expressed in oral SCC, facilitates tumor cell motility, and mediates TN-C matrix deposition. Taken together, these results suggest that EMMPRIN may help regulate oral squamous cell carcinoma invasion." @default.
• W1988232005 created "2016-06-24" @default.
• W1988232005 creator A5009610726 @default.
• W1988232005 creator A5041181056 @default.
• W1988232005 creator A5053944779 @default.
• W1988232005 creator A5061321611 @default.
• W1988232005 creator A5076397217 @default.
• W1988232005 creator A5077604881 @default.
• W1988232005 creator A5085036412 @default.
• W1988232005 creator A5090408123 @default.
• W1988232005 date "2000-01-28" @default.
• W1988232005 modified "2023-10-16" @default.
• W1988232005 title "Expression of EMMPRIN by oral squamous cell carcinoma" @default.
• W1988232005 cites W1551629532 @default.
• W1988232005 cites W1972586003 @default.
• W1988232005 cites W1988563955 @default.
• W1988232005 cites W1993017660 @default.
• W1988232005 cites W2006768453 @default.
• W1988232005 cites W2010571187 @default.
• W1988232005 cites W2026297560 @default.
• W1988232005 cites W2052626837 @default.
• W1988232005 cites W2069522096 @default.
• W1988232005 cites W2095316993 @default.
• W1988232005 cites W2110328298 @default.
• W1988232005 cites W2142376043 @default.
• W1988232005 cites W2151386979 @default.
• W1988232005 cites W2313482528 @default.
• W1988232005 cites W31673539 @default.
• W1988232005 doi "https://doi.org/10.1002/(sici)1097-0215(20000201)85:3<347::aid-ijc9>3.0.co;2-#" @default.
• W1988232005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10652425" @default.
• W1988232005 hasPublicationYear "2000" @default.
• W1988232005 type Work @default.
• W1988232005 sameAs 1988232005 @default.
• W1988232005 citedByCount "44" @default.
• W1988232005 countsByYear W19882320052012 @default.
• W1988232005 countsByYear W19882320052014 @default.
• W1988232005 countsByYear W19882320052015 @default.
• W1988232005 countsByYear W19882320052016 @default.
• W1988232005 countsByYear W19882320052017 @default.
• W1988232005 countsByYear W19882320052018 @default.
• W1988232005 countsByYear W19882320052020 @default.
• W1988232005 countsByYear W19882320052022 @default.
• W1988232005 countsByYear W19882320052023 @default.
• W1988232005 crossrefType "journal-article" @default.
• W1988232005 hasAuthorship W1988232005A5009610726 @default.
• W1988232005 hasAuthorship W1988232005A5041181056 @default.
• W1988232005 hasAuthorship W1988232005A5053944779 @default.
• W1988232005 hasAuthorship W1988232005A5061321611 @default.
• W1988232005 hasAuthorship W1988232005A5076397217 @default.
• W1988232005 hasAuthorship W1988232005A5077604881 @default.
• W1988232005 hasAuthorship W1988232005A5085036412 @default.
• W1988232005 hasAuthorship W1988232005A5090408123 @default.
• W1988232005 hasConcept C109523444 @default.
• W1988232005 hasConcept C142724271 @default.
• W1988232005 hasConcept C1491633281 @default.
• W1988232005 hasConcept C153911025 @default.
• W1988232005 hasConcept C159654299 @default.
• W1988232005 hasConcept C185592680 @default.
• W1988232005 hasConcept C189165786 @default.
• W1988232005 hasConcept C203014093 @default.
• W1988232005 hasConcept C2776126859 @default.
• W1988232005 hasConcept C2776193487 @default.
• W1988232005 hasConcept C2777546739 @default.
• W1988232005 hasConcept C2994460389 @default.
• W1988232005 hasConcept C529295009 @default.
• W1988232005 hasConcept C54355233 @default.
• W1988232005 hasConcept C55493867 @default.
• W1988232005 hasConcept C71924100 @default.
• W1988232005 hasConcept C81885089 @default.
• W1988232005 hasConcept C86492073 @default.
• W1988232005 hasConcept C86803240 @default.
• W1988232005 hasConcept C95444343 @default.
• W1988232005 hasConceptScore W1988232005C109523444 @default.
• W1988232005 hasConceptScore W1988232005C142724271 @default.
• W1988232005 hasConceptScore W1988232005C1491633281 @default.
• W1988232005 hasConceptScore W1988232005C153911025 @default.
• W1988232005 hasConceptScore W1988232005C159654299 @default.
• W1988232005 hasConceptScore W1988232005C185592680 @default.
• W1988232005 hasConceptScore W1988232005C189165786 @default.
• W1988232005 hasConceptScore W1988232005C203014093 @default.
• W1988232005 hasConceptScore W1988232005C2776126859 @default.
• W1988232005 hasConceptScore W1988232005C2776193487 @default.
• W1988232005 hasConceptScore W1988232005C2777546739 @default.
• W1988232005 hasConceptScore W1988232005C2994460389 @default.
• W1988232005 hasConceptScore W1988232005C529295009 @default.
• W1988232005 hasConceptScore W1988232005C54355233 @default.
• W1988232005 hasConceptScore W1988232005C55493867 @default.
• W1988232005 hasConceptScore W1988232005C71924100 @default.
• W1988232005 hasConceptScore W1988232005C81885089 @default.
• W1988232005 hasConceptScore W1988232005C86492073 @default.
• W1988232005 hasConceptScore W1988232005C86803240 @default.
• W1988232005 hasConceptScore W1988232005C95444343 @default.
• W1988232005 hasIssue "3" @default.
• W1988232005 hasLocation W19882320051 @default.
• W1988232005 hasLocation W19882320052 @default.
• W1988232005 hasOpenAccess W1988232005 @default.
• W1988232005 hasPrimaryLocation W19882320051 @default.
• W1988232005 hasRelatedWork W1987669338 @default.

• next