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• W1988236141 endingPage "25" @default.
• W1988236141 startingPage "16" @default.
• W1988236141 abstract "The RNA-binding protein TDP-43 is strongly linked to neurodegeneration. Not only are mutations in the gene encoding TDP-43 associated with ALS and FTLD, but this protein is also a major constituent of pathological intracellular inclusions in these diseases. Recent studies have significantly expanded our understanding of TDP-43 physiology. TDP-43 is now known to play important roles in neuronal RNA metabolism. It binds to and regulates the splicing and stability of numerous RNAs encoding proteins involved in neuronal development, synaptic function and neurodegeneration. Thus, a loss of these essential functions is an attractive hypothesis regarding the role of TDP-43 in neurodegeneration. Moreover, TDP-43 is an aggregation-prone protein and, given the role of toxic protein aggregates in neurodegeneration, a toxic gain-of-function mechanism is another rational hypothesis. Importantly, ALS related mutations modulate the propensity of TDP-43 to aggregate in cell culture. Several recent studies have documented that cytoplasmic TDP-43 aggregates co-localize with stress granule markers. Stress granules are cytoplasmic inclusions that repress translation of a subset of RNAs in times of cellular stress, and several proteins implicated in neurodegeneration (i.e. Ataxin-2 and SMN) interact with stress granules. Thus, understanding the interplay between TDP-43 aggregation, stress granules and the effect of ALS-associated TDP-43 mutations may be the key to understanding the role of TDP-43 in neurodegeneration. We propose two models of TDP-43 aggregate formation. The independent model stipulates that TDP-43 aggregation is independent of stress granule formation, in contrast to the precursor model which presents the idea that stress granule formation contributes to a TDP-43 aggregate seed and that chronic stress leads to concentration-dependent TDP-43 aggregation. This article is part of a Special Issue entitled: RNA-Binding Proteins." @default.
• W1988236141 created "2016-06-24" @default.
• W1988236141 creator A5000872870 @default.
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• W1988236141 creator A5037865809 @default.
• W1988236141 creator A5044342845 @default.
• W1988236141 date "2012-06-01" @default.
• W1988236141 modified "2023-10-17" @default.
• W1988236141 title "TDP-43 aggregation in neurodegeneration: Are stress granules the key?" @default.
• W1988236141 cites W1525431743 @default.
• W1988236141 cites W1570386882 @default.
• W1988236141 cites W1619082318 @default.
• W1988236141 cites W1797354227 @default.
• W1988236141 cites W181468314 @default.
• W1988236141 cites W1964628768 @default.
• W1988236141 cites W1966364136 @default.
• W1988236141 cites W1967443709 @default.
• W1988236141 cites W1971047357 @default.
• W1988236141 cites W1971323868 @default.
• W1988236141 cites W1972376589 @default.
• W1988236141 cites W1975860260 @default.
• W1988236141 cites W1979313188 @default.
• W1988236141 cites W1984145170 @default.
• W1988236141 cites W1985171431 @default.
• W1988236141 cites W1987374983 @default.
• W1988236141 cites W1989068573 @default.
• W1988236141 cites W1989619236 @default.
• W1988236141 cites W1990145006 @default.
• W1988236141 cites W1990584803 @default.
• W1988236141 cites W1991208268 @default.
• W1988236141 cites W1995395394 @default.
• W1988236141 cites W2003618511 @default.
• W1988236141 cites W2006897215 @default.
• W1988236141 cites W2013114762 @default.
• W1988236141 cites W2013482681 @default.
• W1988236141 cites W2018699441 @default.
• W1988236141 cites W2023556666 @default.
• W1988236141 cites W2027420858 @default.
• W1988236141 cites W2027720028 @default.
• W1988236141 cites W2028304454 @default.
• W1988236141 cites W2030654136 @default.
• W1988236141 cites W2031962092 @default.
• W1988236141 cites W2031964319 @default.
• W1988236141 cites W2032719480 @default.
• W1988236141 cites W2034279651 @default.
• W1988236141 cites W2034954321 @default.
• W1988236141 cites W2036545702 @default.
• W1988236141 cites W2044821390 @default.
• W1988236141 cites W2045602910 @default.
• W1988236141 cites W2047267141 @default.
• W1988236141 cites W2047573465 @default.
• W1988236141 cites W2049311171 @default.
• W1988236141 cites W2052137498 @default.
• W1988236141 cites W2056831129 @default.
• W1988236141 cites W2060076138 @default.
• W1988236141 cites W2063183749 @default.
• W1988236141 cites W2069350252 @default.
• W1988236141 cites W2074726646 @default.
• W1988236141 cites W2074795212 @default.
• W1988236141 cites W2075186362 @default.
• W1988236141 cites W2075588816 @default.
• W1988236141 cites W2077829198 @default.
• W1988236141 cites W2078616043 @default.
• W1988236141 cites W2081589139 @default.
• W1988236141 cites W2084208532 @default.
• W1988236141 cites W2084394003 @default.
• W1988236141 cites W2084942172 @default.
• W1988236141 cites W2087672655 @default.
• W1988236141 cites W2092646825 @default.
• W1988236141 cites W2096821445 @default.
• W1988236141 cites W2096948009 @default.
• W1988236141 cites W2097843267 @default.
• W1988236141 cites W2098387574 @default.
• W1988236141 cites W2101042581 @default.
• W1988236141 cites W2102953537 @default.
• W1988236141 cites W2103446696 @default.
• W1988236141 cites W2109140791 @default.
• W1988236141 cites W2112523914 @default.
• W1988236141 cites W2116660354 @default.
• W1988236141 cites W2117428493 @default.
• W1988236141 cites W2118015973 @default.
• W1988236141 cites W2118738728 @default.
• W1988236141 cites W2120434672 @default.
• W1988236141 cites W2126569879 @default.
• W1988236141 cites W2127861463 @default.
• W1988236141 cites W2128398569 @default.
• W1988236141 cites W2128817844 @default.
• W1988236141 cites W2131623079 @default.
• W1988236141 cites W2134530067 @default.
• W1988236141 cites W2134564685 @default.
• W1988236141 cites W2135607950 @default.
• W1988236141 cites W2136949432 @default.
• W1988236141 cites W2138267133 @default.
• W1988236141 cites W2139267086 @default.
• W1988236141 cites W2140112946 @default.
• W1988236141 cites W2141231623 @default.

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