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- W1988253669 abstract "Neuropeptide Y (NPY) is present in both extrinsic symphatetic adrenerigc nerve terminals and intrinsic nerves of the gastrointestinal (GI) tract. Based on this localization a number of functions have been attributed to GI NPY including regulation of blood flow, intestinal fluid and electrolyte transport, and motility. There is nothing currently known, however, about the regulation of its secretion from GI nerves. The effect of choligernic agonists and antagonist on secretion of NPY immunoreactivity (NPY-IR) from the isolated perfused rat stomach was investigated in the present study. Perfusate samples were extracted and concentrated on SepPak cartridges. Basal levels of NPY-IR varied between 98 and 147 fmol/min. Release was stimulated by high potassium concentrations (50 mM) and acetylholine (ACh; 1 μM). ACh-induced secretion was unaffected by atropine, but inhibited by hexamethonium. Further evidence for a nicotinic component in the regulation of NPY-IR secretion was obtained by the finding of hexamethonium-induced reduction in basal secretion and stimulation of secretion by 1,1-dimethyl-4-phenyl-piperazinium (DMPP). In conclusion, cholinergic agonists and antagonists can modulate gastric NPY-IR secretion, and the cholinergic stimulatory effects are probably mediated via nicotinic receptor stimulation at the level of the intrinsic ganglia." @default.
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- W1988253669 date "1992-04-01" @default.
- W1988253669 modified "2023-10-16" @default.
- W1988253669 title "Cholinergic stimulation of neuropeptide Y secretion from the isolated perfused rat stomach" @default.
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- W1988253669 doi "https://doi.org/10.1016/0167-0115(92)90010-r" @default.
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