Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988257501> ?p ?o ?g. }
- W1988257501 endingPage "8650" @default.
- W1988257501 startingPage "8645" @default.
- W1988257501 abstract "Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4, also known as CD152) has been shown to play a major role in the regulation of T cell activation. Its membrane expression is highly regulated by endocytosis and trafficking through the secretory lysosome pathway. Chediak-Higashi syndrome (CHS) is an inherited disorder caused by mutations in the lysosomal trafficking regulator gene, LYST. It results in defective membrane targeting of the proteins present in secretory lysosomes, and it is associated with a variety of features, including a lymphoproliferative syndrome with hemophagocytosis. The murine equivalent of CHS, beige mice, present similar characteristics but do not develop the lymphoproliferative syndrome. We show herein that CTLA-4 is present in enlarged, abnormal vesicles in CHS T cells and is not properly expressed at the cell surface after T cell activation, whereas its surface expression is not impaired. It is therefore proposed that the defective surface expression of CTLA-4 by CHS T cells is involved in the generation of lymphoproliferative disease. This observation may provide insight into the role of CTLA-4 in humans." @default.
- W1988257501 created "2016-06-24" @default.
- W1988257501 creator A5000519957 @default.
- W1988257501 creator A5006297452 @default.
- W1988257501 creator A5018211571 @default.
- W1988257501 creator A5029004287 @default.
- W1988257501 creator A5039812479 @default.
- W1988257501 creator A5047506862 @default.
- W1988257501 creator A5059122189 @default.
- W1988257501 date "1999-07-20" @default.
- W1988257501 modified "2023-10-13" @default.
- W1988257501 title "Defective CTLA-4 cycling pathway in Chediak–Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation" @default.
- W1988257501 cites W1528584436 @default.
- W1988257501 cites W1540441814 @default.
- W1988257501 cites W1572106051 @default.
- W1988257501 cites W1598857912 @default.
- W1988257501 cites W1656896650 @default.
- W1988257501 cites W1661676597 @default.
- W1988257501 cites W1963861811 @default.
- W1988257501 cites W1978373343 @default.
- W1988257501 cites W1999375876 @default.
- W1988257501 cites W2012972418 @default.
- W1988257501 cites W2013944173 @default.
- W1988257501 cites W2015052084 @default.
- W1988257501 cites W2015085911 @default.
- W1988257501 cites W2020775082 @default.
- W1988257501 cites W2040572245 @default.
- W1988257501 cites W2043007190 @default.
- W1988257501 cites W2046739604 @default.
- W1988257501 cites W2048198121 @default.
- W1988257501 cites W2051947926 @default.
- W1988257501 cites W2058001723 @default.
- W1988257501 cites W2061049446 @default.
- W1988257501 cites W2062329960 @default.
- W1988257501 cites W2066822843 @default.
- W1988257501 cites W2076067786 @default.
- W1988257501 cites W2084536008 @default.
- W1988257501 cites W2086815560 @default.
- W1988257501 cites W2089907993 @default.
- W1988257501 cites W2090306908 @default.
- W1988257501 cites W2090481553 @default.
- W1988257501 cites W2093542451 @default.
- W1988257501 cites W2094366129 @default.
- W1988257501 cites W2094991897 @default.
- W1988257501 cites W2101019209 @default.
- W1988257501 cites W2114329158 @default.
- W1988257501 cites W2120499824 @default.
- W1988257501 cites W2123261569 @default.
- W1988257501 cites W2130445686 @default.
- W1988257501 cites W2133166743 @default.
- W1988257501 cites W2144553699 @default.
- W1988257501 cites W2156638024 @default.
- W1988257501 cites W2162466652 @default.
- W1988257501 cites W2163391867 @default.
- W1988257501 cites W2164903177 @default.
- W1988257501 cites W2170844178 @default.
- W1988257501 cites W2239755613 @default.
- W1988257501 cites W28158108 @default.
- W1988257501 cites W2988207268 @default.
- W1988257501 doi "https://doi.org/10.1073/pnas.96.15.8645" @default.
- W1988257501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/17570" @default.
- W1988257501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10411929" @default.
- W1988257501 hasPublicationYear "1999" @default.
- W1988257501 type Work @default.
- W1988257501 sameAs 1988257501 @default.
- W1988257501 citedByCount "77" @default.
- W1988257501 countsByYear W19882575012012 @default.
- W1988257501 countsByYear W19882575012013 @default.
- W1988257501 countsByYear W19882575012014 @default.
- W1988257501 countsByYear W19882575012015 @default.
- W1988257501 countsByYear W19882575012016 @default.
- W1988257501 countsByYear W19882575012017 @default.
- W1988257501 countsByYear W19882575012018 @default.
- W1988257501 countsByYear W19882575012019 @default.
- W1988257501 countsByYear W19882575012020 @default.
- W1988257501 countsByYear W19882575012023 @default.
- W1988257501 crossrefType "journal-article" @default.
- W1988257501 hasAuthorship W1988257501A5000519957 @default.
- W1988257501 hasAuthorship W1988257501A5006297452 @default.
- W1988257501 hasAuthorship W1988257501A5018211571 @default.
- W1988257501 hasAuthorship W1988257501A5029004287 @default.
- W1988257501 hasAuthorship W1988257501A5039812479 @default.
- W1988257501 hasAuthorship W1988257501A5047506862 @default.
- W1988257501 hasAuthorship W1988257501A5059122189 @default.
- W1988257501 hasBestOaLocation W19882575011 @default.
- W1988257501 hasConcept C147483822 @default.
- W1988257501 hasConcept C1491633281 @default.
- W1988257501 hasConcept C154317977 @default.
- W1988257501 hasConcept C181199279 @default.
- W1988257501 hasConcept C185592680 @default.
- W1988257501 hasConcept C202751555 @default.
- W1988257501 hasConcept C203014093 @default.
- W1988257501 hasConcept C21705690 @default.
- W1988257501 hasConcept C2776070026 @default.
- W1988257501 hasConcept C2776090121 @default.
- W1988257501 hasConcept C2780216420 @default.
- W1988257501 hasConcept C28005876 @default.
- W1988257501 hasConcept C2992881475 @default.