FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988261044> ?p ?o ?g. }

• W1988261044 endingPage "139" @default.
• W1988261044 startingPage "133" @default.
• W1988261044 abstract "Nitric oxide is an important biological mediator associated with multiple pathophysiological phenomena, such as platelet aggregation, vasodilation, septic shock, and autoimmune diseases. Prostaglandins, derived from cyclooxygenases, play prominent roles in homeostasis and inflammation. In this study, we characterized the effects of 7HQ derivatives (7-[(4-methylene-5-oxo-2-R-2-tetrahydrofuranyl) methoxy]-3,4-dihydrocarbostyril, where R is methyl, phenyl, p-fluorophenyl and p-phenylphenyl; 7HQ-1,-2,-3 and-4, respectively) in murine RAW 264.7 cells, a macrophage-like cell line. Lipopolysaccharide, the active component of endotoxin, significantly induced the expression of inducible nitric oxide synthase and cyclooxygenase-2, leading to the accumulation of nitrite and prostaglandin E2, respectively. These actions of lipopolysaccharide were inhibited by 7HQ derivatives; additionally, the inhibition of the expression, rather than the activity, of inducible nitric oxide synthase correlated well with that of nitric oxide formation. Western blotting and electrophoretic mobility shift assay results demonstrated that the 7HQ derivatives could effectively inhibit IκB-α degradation and nuclear factor κB (NF-κB) translocation. At higher concentrations, 7HQ derivatives also inhibited cyclooxygenase-2 enzyme activity. These results suggest that 7HQ derivatives exhibit inhibitory effects on lipopolysaccharide-induced nitric oxide production and expression of inducible nitric oxide synthase and cyclooxygenase-2 through inhibition of IκB-α degradation and NF-κB activation." @default.
• W1988261044 created "2016-06-24" @default.
• W1988261044 creator A5000791245 @default.
• W1988261044 creator A5013734423 @default.
• W1988261044 creator A5016825023 @default.
• W1988261044 creator A5049312136 @default.
• W1988261044 creator A5057812012 @default.
• W1988261044 creator A5062140000 @default.
• W1988261044 creator A5062908137 @default.
• W1988261044 creator A5065232422 @default.
• W1988261044 date "2001-04-01" @default.
• W1988261044 modified "2023-10-14" @default.
• W1988261044 title "Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: involvement of IκB-α stabilization" @default.
• W1988261044 cites W1496717884 @default.
• W1988261044 cites W1540820582 @default.
• W1988261044 cites W1585941096 @default.
• W1988261044 cites W1591881963 @default.
• W1988261044 cites W170281222 @default.
• W1988261044 cites W1964620595 @default.
• W1988261044 cites W1986190356 @default.
• W1988261044 cites W1990802251 @default.
• W1988261044 cites W1995692056 @default.
• W1988261044 cites W1999119047 @default.
• W1988261044 cites W2013023382 @default.
• W1988261044 cites W2018905034 @default.
• W1988261044 cites W2033800625 @default.
• W1988261044 cites W2040981816 @default.
• W1988261044 cites W2046983269 @default.
• W1988261044 cites W2050283646 @default.
• W1988261044 cites W2053758653 @default.
• W1988261044 cites W2068987356 @default.
• W1988261044 cites W2070609164 @default.
• W1988261044 cites W2085837280 @default.
• W1988261044 cites W2089747387 @default.
• W1988261044 cites W2149200346 @default.
• W1988261044 cites W2149233326 @default.
• W1988261044 cites W2162102323 @default.
• W1988261044 cites W2290936009 @default.
• W1988261044 cites W2324450935 @default.
• W1988261044 cites W2331176038 @default.
• W1988261044 cites W2766221641 @default.
• W1988261044 cites W4319308505 @default.
• W1988261044 doi "https://doi.org/10.1016/s0014-2999(01)00922-0" @default.
• W1988261044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11334875" @default.
• W1988261044 hasPublicationYear "2001" @default.
• W1988261044 type Work @default.
• W1988261044 sameAs 1988261044 @default.
• W1988261044 citedByCount "17" @default.
• W1988261044 countsByYear W19882610442012 @default.
• W1988261044 countsByYear W19882610442013 @default.
• W1988261044 countsByYear W19882610442015 @default.
• W1988261044 countsByYear W19882610442016 @default.
• W1988261044 countsByYear W19882610442018 @default.
• W1988261044 countsByYear W19882610442022 @default.
• W1988261044 crossrefType "journal-article" @default.
• W1988261044 hasAuthorship W1988261044A5000791245 @default.
• W1988261044 hasAuthorship W1988261044A5013734423 @default.
• W1988261044 hasAuthorship W1988261044A5016825023 @default.
• W1988261044 hasAuthorship W1988261044A5049312136 @default.
• W1988261044 hasAuthorship W1988261044A5057812012 @default.
• W1988261044 hasAuthorship W1988261044A5062140000 @default.
• W1988261044 hasAuthorship W1988261044A5062908137 @default.
• W1988261044 hasAuthorship W1988261044A5065232422 @default.
• W1988261044 hasConcept C134018914 @default.
• W1988261044 hasConcept C178790620 @default.
• W1988261044 hasConcept C181199279 @default.
• W1988261044 hasConcept C185592680 @default.
• W1988261044 hasConcept C2777622882 @default.
• W1988261044 hasConcept C2777956040 @default.
• W1988261044 hasConcept C2778754761 @default.
• W1988261044 hasConcept C2779689624 @default.
• W1988261044 hasConcept C2780664492 @default.
• W1988261044 hasConcept C519581460 @default.
• W1988261044 hasConcept C55493867 @default.
• W1988261044 hasConcept C86803240 @default.
• W1988261044 hasConcept C98274493 @default.
• W1988261044 hasConceptScore W1988261044C134018914 @default.
• W1988261044 hasConceptScore W1988261044C178790620 @default.
• W1988261044 hasConceptScore W1988261044C181199279 @default.
• W1988261044 hasConceptScore W1988261044C185592680 @default.
• W1988261044 hasConceptScore W1988261044C2777622882 @default.
• W1988261044 hasConceptScore W1988261044C2777956040 @default.
• W1988261044 hasConceptScore W1988261044C2778754761 @default.
• W1988261044 hasConceptScore W1988261044C2779689624 @default.
• W1988261044 hasConceptScore W1988261044C2780664492 @default.
• W1988261044 hasConceptScore W1988261044C519581460 @default.
• W1988261044 hasConceptScore W1988261044C55493867 @default.
• W1988261044 hasConceptScore W1988261044C86803240 @default.
• W1988261044 hasConceptScore W1988261044C98274493 @default.
• W1988261044 hasIssue "1-2" @default.
• W1988261044 hasLocation W19882610441 @default.
• W1988261044 hasLocation W19882610442 @default.
• W1988261044 hasOpenAccess W1988261044 @default.
• W1988261044 hasPrimaryLocation W19882610441 @default.
• W1988261044 hasRelatedWork W1903930571 @default.
• W1988261044 hasRelatedWork W1979081200 @default.
• W1988261044 hasRelatedWork W1990567068 @default.
• W1988261044 hasRelatedWork W2040262314 @default.

• next