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• W1988266019 endingPage "9141" @default.
• W1988266019 startingPage "9129" @default.
• W1988266019 abstract "Charge recombination rate constants vary no more than 3-fold for interprotein ET in the Zn-substituted wild type (WT) cytochrome c peroxidase (CcP):cytochrome c (Cc) complex and in complexes with four mutants of the Cc protein (i.e., F82S, F82W, F82Y, and F82I), despite large differences in the ET distance. Theoretical analysis indicates that charge recombination for all complexes involves a combination of tunneling and hopping via Trp191. For three of the five structures (WT and F82S(W)), the protein favors hopping more than that in the other two structures that have longer heme → ZnP distances (F82Y(I)). Experimentally observed biexponential ET kinetics is explained by the complex locking in alternative coupling pathways, where the acceptor hole state is either primarily localized on ZnP (slow phase) or on Trp191 (fast phase). The large conformational differences between the CcP:Cc interface for the F82Y(I) mutants compared to that the WT and F82S(W) complexes are predicted to change the reorganization energies for the CcP:Cc ET reactions because of changes in solvent exposure and interprotein ET distances. Since the recombination reaction is likely to occur in the inverted Marcus regime, an increased reorganization energy compensates the decreased role for hopping recombination (and the longer transfer distance) in the F82Y(I) mutants. Taken together, coupling pathway and reorganization energy effects for the five protein complexes explain the observed insensitivity of recombination kinetics to donor–acceptor distance and docking pose and also reveals how hopping through aromatic residues can accelerate long-range ET." @default.
• W1988266019 created "2016-06-24" @default.
• W1988266019 creator A5000028883 @default.
• W1988266019 creator A5009577668 @default.
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• W1988266019 creator A5049609445 @default.
• W1988266019 creator A5071526287 @default.
• W1988266019 creator A5089695755 @default.
• W1988266019 date "2013-07-29" @default.
• W1988266019 modified "2023-09-28" @default.
• W1988266019 title "Distance-Independent Charge Recombination Kinetics in Cytochrome <i>c</i>–Cytochrome <i>c</i> Peroxidase Complexes: Compensating Changes in the Electronic Coupling and Reorganization Energies" @default.
• W1988266019 cites W180160316 @default.
• W1988266019 cites W1965810021 @default.
• W1988266019 cites W1966040341 @default.
• W1988266019 cites W1968877796 @default.
• W1988266019 cites W1969455508 @default.
• W1988266019 cites W1970809021 @default.
• W1988266019 cites W1970836636 @default.
• W1988266019 cites W1974786218 @default.
• W1988266019 cites W1975236289 @default.
• W1988266019 cites W1979591381 @default.
• W1988266019 cites W1981745234 @default.
• W1988266019 cites W1985878848 @default.
• W1988266019 cites W1994849220 @default.
• W1988266019 cites W1995981473 @default.
• W1988266019 cites W1998840349 @default.
• W1988266019 cites W1999494084 @default.
• W1988266019 cites W2002302207 @default.
• W1988266019 cites W2002551641 @default.
• W1988266019 cites W2007078689 @default.
• W1988266019 cites W2009768028 @default.
• W1988266019 cites W2010072693 @default.
• W1988266019 cites W2019678428 @default.
• W1988266019 cites W2020371482 @default.
• W1988266019 cites W2021762324 @default.
• W1988266019 cites W2023119502 @default.
• W1988266019 cites W2023271753 @default.
• W1988266019 cites W2023504751 @default.
• W1988266019 cites W2026908479 @default.
• W1988266019 cites W2027123970 @default.
• W1988266019 cites W2027408247 @default.
• W1988266019 cites W2029667189 @default.
• W1988266019 cites W2031904472 @default.
• W1988266019 cites W2033990154 @default.
• W1988266019 cites W2036039403 @default.
• W1988266019 cites W2039706195 @default.
• W1988266019 cites W2042164805 @default.
• W1988266019 cites W2042751257 @default.
• W1988266019 cites W2043025079 @default.
• W1988266019 cites W2043333839 @default.
• W1988266019 cites W2044061214 @default.
• W1988266019 cites W2044626212 @default.
• W1988266019 cites W2044990980 @default.
• W1988266019 cites W2046412723 @default.
• W1988266019 cites W2048463929 @default.
• W1988266019 cites W2048870363 @default.
• W1988266019 cites W2050333027 @default.
• W1988266019 cites W2053167395 @default.
• W1988266019 cites W2053268289 @default.
• W1988266019 cites W2055337326 @default.
• W1988266019 cites W2057096657 @default.
• W1988266019 cites W2057664120 @default.
• W1988266019 cites W2058363175 @default.
• W1988266019 cites W2058433292 @default.
• W1988266019 cites W2059303493 @default.
• W1988266019 cites W2061869461 @default.
• W1988266019 cites W2062979963 @default.
• W1988266019 cites W2064040987 @default.
• W1988266019 cites W2067011309 @default.
• W1988266019 cites W2067263502 @default.
• W1988266019 cites W2068650204 @default.
• W1988266019 cites W2070951586 @default.
• W1988266019 cites W2071525418 @default.
• W1988266019 cites W2071595256 @default.
• W1988266019 cites W2072679497 @default.
• W1988266019 cites W2073208997 @default.
• W1988266019 cites W2073534514 @default.
• W1988266019 cites W2074768610 @default.
• W1988266019 cites W2075662351 @default.
• W1988266019 cites W2076407279 @default.
• W1988266019 cites W2077805528 @default.
• W1988266019 cites W2078607719 @default.
• W1988266019 cites W2078986045 @default.
• W1988266019 cites W2079715570 @default.
• W1988266019 cites W2080217267 @default.
• W1988266019 cites W2081255032 @default.
• W1988266019 cites W2081861415 @default.
• W1988266019 cites W2084135044 @default.
• W1988266019 cites W2086057138 @default.
• W1988266019 cites W2086957099 @default.
• W1988266019 cites W2089136615 @default.
• W1988266019 cites W2089802780 @default.
• W1988266019 cites W2091177025 @default.
• W1988266019 cites W2091975638 @default.
• W1988266019 cites W2093701962 @default.
• W1988266019 cites W2094642658 @default.
• W1988266019 cites W2094670033 @default.

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