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- W1988267044 endingPage "1057" @default.
- W1988267044 startingPage "1048" @default.
- W1988267044 abstract "The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). Here, we describe a LEM protein annotated in databases as ‘Ankyrin repeat and LEM domain-containing protein 1’ (Ankle1). We show that Ankle1 is conserved in metazoans and contains a unique C-terminal GIY-YIG motif that confers endonuclease activity in vitro and in vivo. In mammals, Ankle1 is predominantly expressed in hematopoietic tissues. Although most characterized LEM proteins are components of the inner nuclear membrane, ectopic Ankle1 shuttles between cytoplasm and nucleus. Ankle1 enriched in the nucleoplasm induces DNA cleavage and DNA damage response. This activity requires both the catalytic C-terminal GIY-YIG domain and the LEM motif, which binds chromatin via BAF. Hence, Ankle1 is an unusual LEM protein with a GIY-YIG-type endonuclease activity in higher eukaryotes." @default.
- W1988267044 created "2016-06-24" @default.
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- W1988267044 creator A5081263278 @default.
- W1988267044 date "2012-02-15" @default.
- W1988267044 modified "2023-10-10" @default.
- W1988267044 title "The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo" @default.
- W1988267044 cites W1514903902 @default.
- W1988267044 cites W1571470290 @default.
- W1988267044 cites W1601234927 @default.
- W1988267044 cites W1845088912 @default.
- W1988267044 cites W1888731578 @default.
- W1988267044 cites W1891600671 @default.
- W1988267044 cites W1923070576 @default.
- W1988267044 cites W1940968102 @default.
- W1988267044 cites W1941933392 @default.
- W1988267044 cites W1964616851 @default.
- W1988267044 cites W1970954100 @default.
- W1988267044 cites W1972137957 @default.
- W1988267044 cites W1977922844 @default.
- W1988267044 cites W1978331091 @default.
- W1988267044 cites W1978443012 @default.
- W1988267044 cites W1987933754 @default.
- W1988267044 cites W1993928342 @default.
- W1988267044 cites W1994356932 @default.
- W1988267044 cites W1996313023 @default.
- W1988267044 cites W2011742668 @default.
- W1988267044 cites W2013804512 @default.
- W1988267044 cites W2014238550 @default.
- W1988267044 cites W2016619116 @default.
- W1988267044 cites W2019622515 @default.
- W1988267044 cites W2023649556 @default.
- W1988267044 cites W2024945457 @default.
- W1988267044 cites W2025286269 @default.
- W1988267044 cites W2029823040 @default.
- W1988267044 cites W2030464812 @default.
- W1988267044 cites W2036107270 @default.
- W1988267044 cites W2036379096 @default.
- W1988267044 cites W2039933839 @default.
- W1988267044 cites W2040136070 @default.
- W1988267044 cites W2041957522 @default.
- W1988267044 cites W2042730459 @default.
- W1988267044 cites W2042791963 @default.
- W1988267044 cites W2042975711 @default.
- W1988267044 cites W2043479686 @default.
- W1988267044 cites W2043485308 @default.
- W1988267044 cites W2047251447 @default.
- W1988267044 cites W2058162240 @default.
- W1988267044 cites W2058189036 @default.
- W1988267044 cites W2061948650 @default.
- W1988267044 cites W2064194162 @default.
- W1988267044 cites W2070075363 @default.
- W1988267044 cites W2077665958 @default.
- W1988267044 cites W2079185082 @default.
- W1988267044 cites W2080057721 @default.
- W1988267044 cites W2082981422 @default.
- W1988267044 cites W2083847359 @default.
- W1988267044 cites W2091525254 @default.
- W1988267044 cites W2092108900 @default.
- W1988267044 cites W2098484182 @default.
- W1988267044 cites W2100929591 @default.
- W1988267044 cites W2102550611 @default.
- W1988267044 cites W2102613320 @default.
- W1988267044 cites W2103803573 @default.
- W1988267044 cites W2104665954 @default.
- W1988267044 cites W2106882534 @default.
- W1988267044 cites W2115754063 @default.
- W1988267044 cites W2124295853 @default.
- W1988267044 cites W2125268636 @default.
- W1988267044 cites W2126578619 @default.
- W1988267044 cites W2130024105 @default.
- W1988267044 cites W2130242350 @default.
- W1988267044 cites W2130307858 @default.
- W1988267044 cites W2131593425 @default.
- W1988267044 cites W2136583609 @default.
- W1988267044 cites W2140455347 @default.
- W1988267044 cites W2140968763 @default.
- W1988267044 cites W2145893833 @default.
- W1988267044 cites W2149459044 @default.
- W1988267044 cites W2152770371 @default.
- W1988267044 cites W2164697915 @default.
- W1988267044 cites W2164852115 @default.
- W1988267044 cites W2165336894 @default.
- W1988267044 cites W2166187656 @default.
- W1988267044 cites W2166973766 @default.
- W1988267044 cites W2168732780 @default.
- W1988267044 cites W2171721764 @default.
- W1988267044 cites W2171828238 @default.
- W1988267044 doi "https://doi.org/10.1242/jcs.098392" @default.
- W1988267044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335191" @default.