FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988273670> ?p ?o ?g. }

• W1988273670 endingPage "1532" @default.
• W1988273670 startingPage "1525" @default.
• W1988273670 abstract "The mechanism(s) of inhibition of endothelium-dependent relaxation (EDR) by oxidized low-density lipoprotein (Ox-LDL) was examined in isolated porcine coronary arteries and rabbit aortas. Incubation with Ox-LDL but not native LDL caused the inhibition of thrombin- or acetylcholine-induced EDR, whereas A23187-induced EDR was preserved after incubation with Ox-LDL. Lysophosphatidylcholine (lysoPC), which was abundant in Ox-LDL and was found to be transferred from Ox-LDL to endothelial cells, also caused the inhibition of EDR in response to thrombin or acetylcholine but not to A23187. Ox-LDL depleted of lysoPC, which was prepared by phospholipase B, failed to inhibit the vasorelaxation. Coincubation with staurosporine or calphostin C, potent inhibitors of protein kinase C, attenuated the EDR inhibition by Ox-LDL or lysoPC. Phorbol 12-myristate 13-acetate, a specific protein kinase C activator, caused the EDR inhibition, and its effect was attenuated by staurosporine or calphostin C. Furthermore, lysoPC was capable of activating protein kinase C purified from cultured porcine endothelial cells. In conclusion, protein kinase C activation plays a role in the inhibition of surface receptor-mediated EDR by Ox-LDL, and lysoPC transferred from Ox-LDL to endothelial cells may be involved in the activation of protein kinase C." @default.
• W1988273670 created "2016-06-24" @default.
• W1988273670 creator A5015292444 @default.
• W1988273670 creator A5034179596 @default.
• W1988273670 creator A5054464809 @default.
• W1988273670 creator A5055184036 @default.
• W1988273670 creator A5075403819 @default.
• W1988273670 creator A5087424396 @default.
• W1988273670 creator A5091430660 @default.
• W1988273670 date "1993-10-01" @default.
• W1988273670 modified "2023-10-10" @default.
• W1988273670 title "Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL." @default.
• W1988273670 cites W1492921042 @default.
• W1988273670 cites W1507801782 @default.
• W1988273670 cites W1580245730 @default.
• W1988273670 cites W1585941903 @default.
• W1988273670 cites W1589866689 @default.
• W1988273670 cites W1594758412 @default.
• W1988273670 cites W1775749144 @default.
• W1988273670 cites W1857052429 @default.
• W1988273670 cites W1974936467 @default.
• W1988273670 cites W1978470067 @default.
• W1988273670 cites W1982065972 @default.
• W1988273670 cites W1984393490 @default.
• W1988273670 cites W1993884974 @default.
• W1988273670 cites W2001692359 @default.
• W1988273670 cites W2004789344 @default.
• W1988273670 cites W2007886682 @default.
• W1988273670 cites W2030720809 @default.
• W1988273670 cites W2057328587 @default.
• W1988273670 cites W2072740678 @default.
• W1988273670 cites W2075068728 @default.
• W1988273670 cites W2075473225 @default.
• W1988273670 cites W2076332509 @default.
• W1988273670 cites W2104573407 @default.
• W1988273670 cites W2115508204 @default.
• W1988273670 cites W2135189810 @default.
• W1988273670 cites W2154744488 @default.
• W1988273670 cites W2300552860 @default.
• W1988273670 cites W4293247451 @default.
• W1988273670 doi "https://doi.org/10.1161/01.atv.13.10.1525" @default.
• W1988273670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8399090" @default.
• W1988273670 hasPublicationYear "1993" @default.
• W1988273670 type Work @default.
• W1988273670 sameAs 1988273670 @default.
• W1988273670 citedByCount "72" @default.
• W1988273670 countsByYear W19882736702012 @default.
• W1988273670 crossrefType "journal-article" @default.
• W1988273670 hasAuthorship W1988273670A5015292444 @default.
• W1988273670 hasAuthorship W1988273670A5034179596 @default.
• W1988273670 hasAuthorship W1988273670A5054464809 @default.
• W1988273670 hasAuthorship W1988273670A5055184036 @default.
• W1988273670 hasAuthorship W1988273670A5075403819 @default.
• W1988273670 hasAuthorship W1988273670A5087424396 @default.
• W1988273670 hasAuthorship W1988273670A5091430660 @default.
• W1988273670 hasBestOaLocation W19882736701 @default.
• W1988273670 hasConcept C126322002 @default.
• W1988273670 hasConcept C153911025 @default.
• W1988273670 hasConcept C170493617 @default.
• W1988273670 hasConcept C184235292 @default.
• W1988273670 hasConcept C185592680 @default.
• W1988273670 hasConcept C195794163 @default.
• W1988273670 hasConcept C2776330855 @default.
• W1988273670 hasConcept C2777292125 @default.
• W1988273670 hasConcept C2778596009 @default.
• W1988273670 hasConcept C2778918659 @default.
• W1988273670 hasConcept C2779084600 @default.
• W1988273670 hasConcept C2780043322 @default.
• W1988273670 hasConcept C2780245509 @default.
• W1988273670 hasConcept C2781168148 @default.
• W1988273670 hasConcept C41625074 @default.
• W1988273670 hasConcept C55493867 @default.
• W1988273670 hasConcept C71924100 @default.
• W1988273670 hasConcept C86803240 @default.
• W1988273670 hasConcept C88045685 @default.
• W1988273670 hasConcept C89560881 @default.
• W1988273670 hasConcept C97029542 @default.
• W1988273670 hasConceptScore W1988273670C126322002 @default.
• W1988273670 hasConceptScore W1988273670C153911025 @default.
• W1988273670 hasConceptScore W1988273670C170493617 @default.
• W1988273670 hasConceptScore W1988273670C184235292 @default.
• W1988273670 hasConceptScore W1988273670C185592680 @default.
• W1988273670 hasConceptScore W1988273670C195794163 @default.
• W1988273670 hasConceptScore W1988273670C2776330855 @default.
• W1988273670 hasConceptScore W1988273670C2777292125 @default.
• W1988273670 hasConceptScore W1988273670C2778596009 @default.
• W1988273670 hasConceptScore W1988273670C2778918659 @default.
• W1988273670 hasConceptScore W1988273670C2779084600 @default.
• W1988273670 hasConceptScore W1988273670C2780043322 @default.
• W1988273670 hasConceptScore W1988273670C2780245509 @default.
• W1988273670 hasConceptScore W1988273670C2781168148 @default.
• W1988273670 hasConceptScore W1988273670C41625074 @default.
• W1988273670 hasConceptScore W1988273670C55493867 @default.
• W1988273670 hasConceptScore W1988273670C71924100 @default.
• W1988273670 hasConceptScore W1988273670C86803240 @default.
• W1988273670 hasConceptScore W1988273670C88045685 @default.
• W1988273670 hasConceptScore W1988273670C89560881 @default.
• W1988273670 hasConceptScore W1988273670C97029542 @default.

• next