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- W1988282058 endingPage "688" @default.
- W1988282058 startingPage "679" @default.
- W1988282058 abstract "Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs. In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC. Since, many studies have validated this approach, but despite the promise of PTC readthrough therapies, the mechanisms of translation termination remain to be precisely elucidated before even more progress can be made. Here, we review the molecular basis for PTC readthrough in eukaryotes and describe currently available compounds with significant therapeutic potential for treating genetic disorders and cancer." @default.
- W1988282058 created "2016-06-24" @default.
- W1988282058 creator A5026251524 @default.
- W1988282058 creator A5028426279 @default.
- W1988282058 creator A5032686287 @default.
- W1988282058 creator A5090435222 @default.
- W1988282058 date "2012-11-01" @default.
- W1988282058 modified "2023-10-11" @default.
- W1988282058 title "Sense from nonsense: therapies for premature stop codon diseases" @default.
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