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- W1988291197 abstract "Analysis of sister-chromatid exchange (SCE) has been shown to be a sensitive and reproducible method for detecting the action of mutagens and carcinogens. We have succeeded in establishing a reliable technique which allows to perform SCE in preimplantation embryos in order to make the pre-uterine stages of development accessible to routine detection of DNA damage. Using the mouse strain and technique described, approximately 30-40% of mice will mate successfully after synchronization and spontaneous ovulation. From 3 pregnant females, about 30 four- to eight-cell embryos will be obtained, representing one experimental group providing approximately 50-80 two-S-phase labelled metaphases with a SCE frequency baseline below 6 exchanges." @default.
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- W1988291197 date "1985-02-01" @default.
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- W1988291197 title "A method for analysing sister-chromatid exchange in mouse preimplantation embryos" @default.
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- W1988291197 doi "https://doi.org/10.1016/0165-1161(85)90014-7" @default.
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