FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988291240> ?p ?o ?g. }

• W1988291240 endingPage "16035" @default.
• W1988291240 startingPage "16030" @default.
• W1988291240 abstract "In addition to forming gap-junction channels, a subset of connexins (Cxs) also form functional hemichannels. Most hemichannels are activated by depolarization, and opening depends critically on the external Ca 2+ concentration. Here we describe the mechanisms of action and the structural determinants underlying the Ca 2+ regulation of Cx32 hemichannels. At millimolar calcium concentrations, hemichannel voltage gating to the full open state of ≈90 pS is inhibited, and ion conduction at negative voltages of the partially open hemichannels (≈18 pS) is blocked. Thus, divalent cation blockage should be considered as a physiological mechanism to protect the cell from the potentially adverse effects of leaky hemichannels. A ring of 12 Asp residues within the external vestibule of the pore is responsible for the binding of Ca 2+ that accounts for both pore occlusion and blockage of gating. The residue Asp-169 of one subunit and the Asp-178 of an adjacent subunit must be arranged precisely to allow interactions with Ca 2+ to occur. Interestingly, a naturally occurring mutation (D178Y) that causes an inherited peripheral neuropathy induces a complete Ca 2+ deregulation of Cx32 hemichannel activity, suggesting that this dysfunction may be involved in the pathogenesis of the neuropathy." @default.
• W1988291240 created "2016-06-24" @default.
• W1988291240 creator A5003169178 @default.
• W1988291240 creator A5022421790 @default.
• W1988291240 creator A5036549437 @default.
• W1988291240 creator A5061960548 @default.
• W1988291240 creator A5068939181 @default.
• W1988291240 date "2003-12-08" @default.
• W1988291240 modified "2023-10-18" @default.
• W1988291240 title "Molecular basis of calcium regulation in connexin-32 hemichannels" @default.
• W1988291240 cites W123989659 @default.
• W1988291240 cites W1517261517 @default.
• W1988291240 cites W1901485302 @default.
• W1988291240 cites W1914765280 @default.
• W1988291240 cites W1971627794 @default.
• W1988291240 cites W1972920523 @default.
• W1988291240 cites W1986851157 @default.
• W1988291240 cites W1997215245 @default.
• W1988291240 cites W2006129103 @default.
• W1988291240 cites W2007854449 @default.
• W1988291240 cites W2015595997 @default.
• W1988291240 cites W2016665408 @default.
• W1988291240 cites W2017203200 @default.
• W1988291240 cites W2024461475 @default.
• W1988291240 cites W2034556040 @default.
• W1988291240 cites W2050159014 @default.
• W1988291240 cites W2061225022 @default.
• W1988291240 cites W2066140320 @default.
• W1988291240 cites W2080202616 @default.
• W1988291240 cites W2081081246 @default.
• W1988291240 cites W2089686726 @default.
• W1988291240 cites W2098712686 @default.
• W1988291240 cites W2107163147 @default.
• W1988291240 cites W2109127883 @default.
• W1988291240 cites W2113630671 @default.
• W1988291240 cites W2125511062 @default.
• W1988291240 cites W2134046709 @default.
• W1988291240 cites W2144759791 @default.
• W1988291240 cites W2146692959 @default.
• W1988291240 cites W2147851692 @default.
• W1988291240 cites W2161194374 @default.
• W1988291240 cites W2161305913 @default.
• W1988291240 cites W2171863507 @default.
• W1988291240 cites W3021036333 @default.
• W1988291240 doi "https://doi.org/10.1073/pnas.2530348100" @default.
• W1988291240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/307687" @default.
• W1988291240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14663144" @default.
• W1988291240 hasPublicationYear "2003" @default.
• W1988291240 type Work @default.
• W1988291240 sameAs 1988291240 @default.
• W1988291240 citedByCount "153" @default.
• W1988291240 countsByYear W19882912402012 @default.
• W1988291240 countsByYear W19882912402013 @default.
• W1988291240 countsByYear W19882912402014 @default.
• W1988291240 countsByYear W19882912402015 @default.
• W1988291240 countsByYear W19882912402016 @default.
• W1988291240 countsByYear W19882912402017 @default.
• W1988291240 countsByYear W19882912402018 @default.
• W1988291240 countsByYear W19882912402019 @default.
• W1988291240 countsByYear W19882912402020 @default.
• W1988291240 countsByYear W19882912402021 @default.
• W1988291240 countsByYear W19882912402022 @default.
• W1988291240 countsByYear W19882912402023 @default.
• W1988291240 crossrefType "journal-article" @default.
• W1988291240 hasAuthorship W1988291240A5003169178 @default.
• W1988291240 hasAuthorship W1988291240A5022421790 @default.
• W1988291240 hasAuthorship W1988291240A5036549437 @default.
• W1988291240 hasAuthorship W1988291240A5061960548 @default.
• W1988291240 hasAuthorship W1988291240A5068939181 @default.
• W1988291240 hasBestOaLocation W19882912402 @default.
• W1988291240 hasConcept C104292427 @default.
• W1988291240 hasConcept C104317684 @default.
• W1988291240 hasConcept C12554922 @default.
• W1988291240 hasConcept C158157758 @default.
• W1988291240 hasConcept C170493617 @default.
• W1988291240 hasConcept C178790620 @default.
• W1988291240 hasConcept C185592680 @default.
• W1988291240 hasConcept C194544171 @default.
• W1988291240 hasConcept C2780228694 @default.
• W1988291240 hasConcept C4141045 @default.
• W1988291240 hasConcept C50254741 @default.
• W1988291240 hasConcept C519063684 @default.
• W1988291240 hasConcept C55493867 @default.
• W1988291240 hasConcept C74884574 @default.
• W1988291240 hasConcept C79879829 @default.
• W1988291240 hasConcept C86803240 @default.
• W1988291240 hasConcept C95444343 @default.
• W1988291240 hasConceptScore W1988291240C104292427 @default.
• W1988291240 hasConceptScore W1988291240C104317684 @default.
• W1988291240 hasConceptScore W1988291240C12554922 @default.
• W1988291240 hasConceptScore W1988291240C158157758 @default.
• W1988291240 hasConceptScore W1988291240C170493617 @default.
• W1988291240 hasConceptScore W1988291240C178790620 @default.
• W1988291240 hasConceptScore W1988291240C185592680 @default.
• W1988291240 hasConceptScore W1988291240C194544171 @default.
• W1988291240 hasConceptScore W1988291240C2780228694 @default.
• W1988291240 hasConceptScore W1988291240C4141045 @default.
• W1988291240 hasConceptScore W1988291240C50254741 @default.

• next