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- W1988294938 abstract "DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs. Anti-topoisomerase drugs can be divided into two main classes: cleavable complex poisons and catalytic inhibitors. The cleavable complex poisons are very effective as anticancer drugs but are also potent inducers of chromosome aberrations so they can cause secondary malignancies. Catalytic inhibitors are cytotoxic but they do not induce chromosome aberrations. Knowledge about the mechanism of action of topoisomerase inhibitors is important to determine the best anti-topoisomerase combinations, with a reduced risk of induction of secondary malignancies." @default.
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- W1988294938 date "2000-12-01" @default.
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- W1988294938 title "Anti-topoisomerase drugs as potent inducers of chromosomal aberrations" @default.
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- W1988294938 doi "https://doi.org/10.1590/s1415-47572000000400052" @default.
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