FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988304937> ?p ?o ?g. }

• W1988304937 endingPage "2498" @default.
• W1988304937 startingPage "2494" @default.
• W1988304937 abstract "Neuroglobin is a newly identified vertebrate globin that binds O2 and is expressed in cerebral neurons. We found recently that neuronal expression of neuroglobin is stimulated by hypoxia and ischemia and protects neurons from hypoxic injury. Here we report that, like hemoglobin and myoglobin, neuroglobin expression can also be induced by hemin. Induction was concentration dependent and time dependent, with maximal (about 4-fold) increases in neuroglobin mRNA and protein levels occurring with 50 μM hemin and at 8 to 24 hours. The inductive effect of hemin was attenuated by the protein kinase G inhibitor KT5823 and the soluble guanylate cyclase inhibitor LY83583, was mimicked by treatment with 8-bromo–cyclic guanosine 3′,5′-monophosphate, and was accompanied by a greater than 10-fold increase in cGMP levels, suggesting that it is mediated through protein kinase G and soluble guanylate cyclase. In contrast, hypoxic induction of neuroglobin was blocked by the mitogen-activated protein kinase/extracellular signal–regulated kinase kinase inhibitor PD98059, indicating that hemin and hypoxia regulate neuroglobin expression by different mechanisms. These results provide evidence for regulation of neuroglobin expression by at least 2 signal transduction pathways." @default.
• W1988304937 created "2016-06-24" @default.
• W1988304937 creator A5020577454 @default.
• W1988304937 creator A5027085700 @default.
• W1988304937 creator A5073411736 @default.
• W1988304937 creator A5073729732 @default.
• W1988304937 date "2002-10-01" @default.
• W1988304937 modified "2023-09-29" @default.
• W1988304937 title "Hemin induces neuroglobin expression in neural cells" @default.
• W1988304937 cites W105320007 @default.
• W1988304937 cites W1518210230 @default.
• W1988304937 cites W1550815160 @default.
• W1988304937 cites W1653986885 @default.
• W1988304937 cites W1963550954 @default.
• W1988304937 cites W1967855521 @default.
• W1988304937 cites W1987522740 @default.
• W1988304937 cites W1990293965 @default.
• W1988304937 cites W1999086913 @default.
• W1988304937 cites W2005558408 @default.
• W1988304937 cites W2011417221 @default.
• W1988304937 cites W2016220986 @default.
• W1988304937 cites W2016643929 @default.
• W1988304937 cites W202297633 @default.
• W1988304937 cites W2027934896 @default.
• W1988304937 cites W2041614019 @default.
• W1988304937 cites W2046023315 @default.
• W1988304937 cites W2061188498 @default.
• W1988304937 cites W2066960428 @default.
• W1988304937 cites W2075610315 @default.
• W1988304937 cites W2080766637 @default.
• W1988304937 cites W2092184085 @default.
• W1988304937 cites W2093292621 @default.
• W1988304937 cites W2120324273 @default.
• W1988304937 cites W2123939826 @default.
• W1988304937 cites W2130553976 @default.
• W1988304937 cites W2130933110 @default.
• W1988304937 cites W2136239808 @default.
• W1988304937 cites W2471747790 @default.
• W1988304937 cites W3082816727 @default.
• W1988304937 cites W4236819860 @default.
• W1988304937 cites W93143862 @default.
• W1988304937 doi "https://doi.org/10.1182/blood-2002-01-0280" @default.
• W1988304937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12239161" @default.
• W1988304937 hasPublicationYear "2002" @default.
• W1988304937 type Work @default.
• W1988304937 sameAs 1988304937 @default.
• W1988304937 citedByCount "88" @default.
• W1988304937 countsByYear W19883049372012 @default.
• W1988304937 countsByYear W19883049372013 @default.
• W1988304937 countsByYear W19883049372014 @default.
• W1988304937 countsByYear W19883049372015 @default.
• W1988304937 countsByYear W19883049372016 @default.
• W1988304937 countsByYear W19883049372017 @default.
• W1988304937 countsByYear W19883049372018 @default.
• W1988304937 countsByYear W19883049372019 @default.
• W1988304937 countsByYear W19883049372020 @default.
• W1988304937 countsByYear W19883049372021 @default.
• W1988304937 countsByYear W19883049372022 @default.
• W1988304937 crossrefType "journal-article" @default.
• W1988304937 hasAuthorship W1988304937A5020577454 @default.
• W1988304937 hasAuthorship W1988304937A5027085700 @default.
• W1988304937 hasAuthorship W1988304937A5073411736 @default.
• W1988304937 hasAuthorship W1988304937A5073729732 @default.
• W1988304937 hasBestOaLocation W19883049371 @default.
• W1988304937 hasConcept C125996951 @default.
• W1988304937 hasConcept C134018914 @default.
• W1988304937 hasConcept C153911025 @default.
• W1988304937 hasConcept C181199279 @default.
• W1988304937 hasConcept C184235292 @default.
• W1988304937 hasConcept C185592680 @default.
• W1988304937 hasConcept C199217515 @default.
• W1988304937 hasConcept C2776217839 @default.
• W1988304937 hasConcept C2776318716 @default.
• W1988304937 hasConcept C2777723881 @default.
• W1988304937 hasConcept C2778917026 @default.
• W1988304937 hasConcept C2780994212 @default.
• W1988304937 hasConcept C519581460 @default.
• W1988304937 hasConcept C55493867 @default.
• W1988304937 hasConcept C62478195 @default.
• W1988304937 hasConcept C86803240 @default.
• W1988304937 hasConcept C90934575 @default.
• W1988304937 hasConcept C95444343 @default.
• W1988304937 hasConcept C97029542 @default.
• W1988304937 hasConceptScore W1988304937C125996951 @default.
• W1988304937 hasConceptScore W1988304937C134018914 @default.
• W1988304937 hasConceptScore W1988304937C153911025 @default.
• W1988304937 hasConceptScore W1988304937C181199279 @default.
• W1988304937 hasConceptScore W1988304937C184235292 @default.
• W1988304937 hasConceptScore W1988304937C185592680 @default.
• W1988304937 hasConceptScore W1988304937C199217515 @default.
• W1988304937 hasConceptScore W1988304937C2776217839 @default.
• W1988304937 hasConceptScore W1988304937C2776318716 @default.
• W1988304937 hasConceptScore W1988304937C2777723881 @default.
• W1988304937 hasConceptScore W1988304937C2778917026 @default.
• W1988304937 hasConceptScore W1988304937C2780994212 @default.
• W1988304937 hasConceptScore W1988304937C519581460 @default.
• W1988304937 hasConceptScore W1988304937C55493867 @default.
• W1988304937 hasConceptScore W1988304937C62478195 @default.

• next