FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988312440> ?p ?o ?g. }

• W1988312440 endingPage "275" @default.
• W1988312440 startingPage "268" @default.
• W1988312440 abstract "The glutamate receptor was one of the most intensely investigated targets for neuroprotection. However, numerous clinical trials of glutamate receptor antagonists for the treatment of stroke were unsuccessful. These failures have led to pessimism in the field. But recent advances could provide hope for the future. This minireview looks beyond the traditional mechanism of glutamate-receptor-driven excitotoxicity to identify other mechanisms of ionic imbalance. These advances include findings implicating sodium–calcium exchangers, hemichannels, volume-regulated anion channels, acid-sensing channels, transient receptor potential channels, nonselective cation channels and signaling cascades that mediate crosstalk between redundant pathways of cell death. Further in vivo validation of these pathways could ultimately lead us to new therapeutic targets for stroke, trauma and neurodegeneration. The glutamate receptor was one of the most intensely investigated targets for neuroprotection. However, numerous clinical trials of glutamate receptor antagonists for the treatment of stroke were unsuccessful. These failures have led to pessimism in the field. But recent advances could provide hope for the future. This minireview looks beyond the traditional mechanism of glutamate-receptor-driven excitotoxicity to identify other mechanisms of ionic imbalance. These advances include findings implicating sodium–calcium exchangers, hemichannels, volume-regulated anion channels, acid-sensing channels, transient receptor potential channels, nonselective cation channels and signaling cascades that mediate crosstalk between redundant pathways of cell death. Further in vivo validation of these pathways could ultimately lead us to new therapeutic targets for stroke, trauma and neurodegeneration." @default.
• W1988312440 created "2016-06-24" @default.
• W1988312440 creator A5018456621 @default.
• W1988312440 creator A5048877475 @default.
• W1988312440 creator A5052583243 @default.
• W1988312440 creator A5088592099 @default.
• W1988312440 creator A5091447153 @default.
• W1988312440 date "2008-05-01" @default.
• W1988312440 modified "2023-10-18" @default.
• W1988312440 title "Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke" @default.
• W1988312440 cites W1483800511 @default.
• W1988312440 cites W1533853049 @default.
• W1988312440 cites W1556471290 @default.
• W1988312440 cites W1557582259 @default.
• W1988312440 cites W1593655973 @default.
• W1988312440 cites W1631348406 @default.
• W1988312440 cites W1902460967 @default.
• W1988312440 cites W1963909386 @default.
• W1988312440 cites W1964164725 @default.
• W1988312440 cites W1964260585 @default.
• W1988312440 cites W1970367133 @default.
• W1988312440 cites W1980429797 @default.
• W1988312440 cites W1980899641 @default.
• W1988312440 cites W1987211464 @default.
• W1988312440 cites W1989102363 @default.
• W1988312440 cites W1992177920 @default.
• W1988312440 cites W1993781471 @default.
• W1988312440 cites W1994757585 @default.
• W1988312440 cites W1995256270 @default.
• W1988312440 cites W1998688669 @default.
• W1988312440 cites W1999242709 @default.
• W1988312440 cites W2007859668 @default.
• W1988312440 cites W2008303238 @default.
• W1988312440 cites W2012948051 @default.
• W1988312440 cites W2015725815 @default.
• W1988312440 cites W2016997908 @default.
• W1988312440 cites W2017505808 @default.
• W1988312440 cites W2018043371 @default.
• W1988312440 cites W2019163121 @default.
• W1988312440 cites W2020279479 @default.
• W1988312440 cites W2025576506 @default.
• W1988312440 cites W2032741148 @default.
• W1988312440 cites W2034194515 @default.
• W1988312440 cites W2036465941 @default.
• W1988312440 cites W2040710878 @default.
• W1988312440 cites W2057823004 @default.
• W1988312440 cites W2062513416 @default.
• W1988312440 cites W2063541383 @default.
• W1988312440 cites W2064197300 @default.
• W1988312440 cites W2066581734 @default.
• W1988312440 cites W2067775666 @default.
• W1988312440 cites W2068685568 @default.
• W1988312440 cites W2072926617 @default.
• W1988312440 cites W2079352525 @default.
• W1988312440 cites W2082782176 @default.
• W1988312440 cites W2083204774 @default.
• W1988312440 cites W2083759504 @default.
• W1988312440 cites W2084812099 @default.
• W1988312440 cites W2086688096 @default.
• W1988312440 cites W2087140031 @default.
• W1988312440 cites W2089064616 @default.
• W1988312440 cites W2091997132 @default.
• W1988312440 cites W2092474526 @default.
• W1988312440 cites W2094522589 @default.
• W1988312440 cites W2101484677 @default.
• W1988312440 cites W2102087494 @default.
• W1988312440 cites W2102732075 @default.
• W1988312440 cites W2102881079 @default.
• W1988312440 cites W2112140076 @default.
• W1988312440 cites W2114091391 @default.
• W1988312440 cites W2116447221 @default.
• W1988312440 cites W2117339662 @default.
• W1988312440 cites W2119856586 @default.
• W1988312440 cites W2119996978 @default.
• W1988312440 cites W2123152434 @default.
• W1988312440 cites W2126190154 @default.
• W1988312440 cites W2134046709 @default.
• W1988312440 cites W2135563479 @default.
• W1988312440 cites W2138295167 @default.
• W1988312440 cites W2153469644 @default.
• W1988312440 cites W2157368934 @default.
• W1988312440 cites W2161056273 @default.
• W1988312440 cites W2161930006 @default.
• W1988312440 cites W2166505057 @default.
• W1988312440 cites W2167318614 @default.
• W1988312440 cites W2410112552 @default.
• W1988312440 cites W2792583460 @default.
• W1988312440 cites W61928364 @default.
• W1988312440 doi "https://doi.org/10.1016/j.tips.2008.02.003" @default.
• W1988312440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18384889" @default.
• W1988312440 hasPublicationYear "2008" @default.
• W1988312440 type Work @default.
• W1988312440 sameAs 1988312440 @default.
• W1988312440 citedByCount "208" @default.
• W1988312440 countsByYear W19883124402012 @default.
• W1988312440 countsByYear W19883124402013 @default.
• W1988312440 countsByYear W19883124402014 @default.
• W1988312440 countsByYear W19883124402015 @default.

• next