FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988313407> ?p ?o ?g. }

• W1988313407 endingPage "15428" @default.
• W1988313407 startingPage "15423" @default.
• W1988313407 abstract "Transcriptional regulation in the archaea involves a mosaic of DNA-binding proteins frequently (although not exclusively) of bacterial type, modulating a eukaryal-type core transcription apparatus. Methanocaldococcus jannaschii (Mja) Ptr2, a homologue of the Lrp/AsnC family of bacterial transcription regulators that are among the most widely disseminated archaeal DNA-binding proteins, has been shown to activate transcription by its conjugate hyperthermophilic RNA polymerase. Here, two in vitro systems have been exploited to show that Ptr2 and a Lrp homologue from the thermophile Methanothermococcus thermolithotrophicus (Mth) activate transcription over a approximately 40 degrees C range, in conjunction with their cognate TATA-binding proteins (TBPs) and with heterologous TBPs. A closely related homologue from the mesophile Methanococcus maripaludis (Mma) is nearly inert as a transcriptional activator, but a cluster of mutations that converts a surface patch of Mma Lrp to identity with Ptr2 confers transcriptional activity. Mja, Mth, and Mma TBPs are interchangeable for basal transcription, but their ability to support Lrp-mediated transcriptional activation varies widely, with Mja TBP the most active and Mth TBP the least active partner. The implications of this finding for understanding the roles of TBP paralogues in supporting the gene-regulatory repertoires of archaeal genomes are briefly noted." @default.
• W1988313407 created "2016-06-24" @default.
• W1988313407 creator A5074944002 @default.
• W1988313407 creator A5085544864 @default.
• W1988313407 date "2005-10-17" @default.
• W1988313407 modified "2023-10-05" @default.
• W1988313407 title "An expanding family of archaeal transcriptional activators" @default.
• W1988313407 cites W1509729044 @default.
• W1988313407 cites W1532587329 @default.
• W1988313407 cites W1584653951 @default.
• W1988313407 cites W1604102349 @default.
• W1988313407 cites W1935374737 @default.
• W1988313407 cites W1966825133 @default.
• W1988313407 cites W1973152779 @default.
• W1988313407 cites W1976628853 @default.
• W1988313407 cites W1981577753 @default.
• W1988313407 cites W2000341955 @default.
• W1988313407 cites W2004860320 @default.
• W1988313407 cites W2016709199 @default.
• W1988313407 cites W2039429468 @default.
• W1988313407 cites W2041686178 @default.
• W1988313407 cites W2047538154 @default.
• W1988313407 cites W2062551069 @default.
• W1988313407 cites W2070280762 @default.
• W1988313407 cites W2081839590 @default.
• W1988313407 cites W2083820465 @default.
• W1988313407 cites W2091080139 @default.
• W1988313407 cites W2099775990 @default.
• W1988313407 cites W2104853505 @default.
• W1988313407 cites W2117086910 @default.
• W1988313407 cites W2140860400 @default.
• W1988313407 cites W2146265443 @default.
• W1988313407 cites W2154363390 @default.
• W1988313407 cites W2157714710 @default.
• W1988313407 cites W2160939948 @default.
• W1988313407 cites W2413405954 @default.
• W1988313407 doi "https://doi.org/10.1073/pnas.0508043102" @default.
• W1988313407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1266154" @default.
• W1988313407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16230629" @default.
• W1988313407 hasPublicationYear "2005" @default.
• W1988313407 type Work @default.
• W1988313407 sameAs 1988313407 @default.
• W1988313407 citedByCount "25" @default.
• W1988313407 countsByYear W19883134072012 @default.
• W1988313407 countsByYear W19883134072014 @default.
• W1988313407 countsByYear W19883134072015 @default.
• W1988313407 countsByYear W19883134072016 @default.
• W1988313407 countsByYear W19883134072017 @default.
• W1988313407 countsByYear W19883134072019 @default.
• W1988313407 crossrefType "journal-article" @default.
• W1988313407 hasAuthorship W1988313407A5074944002 @default.
• W1988313407 hasAuthorship W1988313407A5085544864 @default.
• W1988313407 hasBestOaLocation W19883134071 @default.
• W1988313407 hasConcept C101762097 @default.
• W1988313407 hasConcept C104317684 @default.
• W1988313407 hasConcept C138885662 @default.
• W1988313407 hasConcept C144825837 @default.
• W1988313407 hasConcept C150194340 @default.
• W1988313407 hasConcept C179926584 @default.
• W1988313407 hasConcept C27153228 @default.
• W1988313407 hasConcept C2776878370 @default.
• W1988313407 hasConcept C2909959438 @default.
• W1988313407 hasConcept C41895202 @default.
• W1988313407 hasConcept C54355233 @default.
• W1988313407 hasConcept C550995028 @default.
• W1988313407 hasConcept C552990157 @default.
• W1988313407 hasConcept C86339819 @default.
• W1988313407 hasConcept C86803240 @default.
• W1988313407 hasConcept C94966510 @default.
• W1988313407 hasConcept C95444343 @default.
• W1988313407 hasConceptScore W1988313407C101762097 @default.
• W1988313407 hasConceptScore W1988313407C104317684 @default.
• W1988313407 hasConceptScore W1988313407C138885662 @default.
• W1988313407 hasConceptScore W1988313407C144825837 @default.
• W1988313407 hasConceptScore W1988313407C150194340 @default.
• W1988313407 hasConceptScore W1988313407C179926584 @default.
• W1988313407 hasConceptScore W1988313407C27153228 @default.
• W1988313407 hasConceptScore W1988313407C2776878370 @default.
• W1988313407 hasConceptScore W1988313407C2909959438 @default.
• W1988313407 hasConceptScore W1988313407C41895202 @default.
• W1988313407 hasConceptScore W1988313407C54355233 @default.
• W1988313407 hasConceptScore W1988313407C550995028 @default.
• W1988313407 hasConceptScore W1988313407C552990157 @default.
• W1988313407 hasConceptScore W1988313407C86339819 @default.
• W1988313407 hasConceptScore W1988313407C86803240 @default.
• W1988313407 hasConceptScore W1988313407C94966510 @default.
• W1988313407 hasConceptScore W1988313407C95444343 @default.
• W1988313407 hasIssue "43" @default.
• W1988313407 hasLocation W19883134071 @default.
• W1988313407 hasLocation W19883134072 @default.
• W1988313407 hasLocation W19883134073 @default.
• W1988313407 hasLocation W19883134074 @default.
• W1988313407 hasOpenAccess W1988313407 @default.
• W1988313407 hasPrimaryLocation W19883134071 @default.
• W1988313407 hasRelatedWork W2011280168 @default.
• W1988313407 hasRelatedWork W2020299722 @default.
• W1988313407 hasRelatedWork W2054054692 @default.
• W1988313407 hasRelatedWork W2060511970 @default.

• next