Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988323278> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1988323278 endingPage "194" @default.
- W1988323278 startingPage "194" @default.
- W1988323278 abstract "Anticancer drugs are designed to inhibit tumor cell proliferation by interacting with DNA and altering cellular growth factors. When released into the waterbodies of municipal and hospital effluents these pharmaceutical compounds may pose a risk to non-target aquatic organisms, due to their mode of action (cytotoxic, genotoxic, mutagenic and teratogenic). The present study aimed to assess the ecotoxicological potential of the alkylating agent cisplatin (CisPt) to the polychaete Nereis diversicolor, at a range of relevant environmental concentrations (i.e. 0.1, 10 and 100 ng Pt L− 1). Behavioural impairment (burrowing kinetic impairment), ion pump effects (SR Ca2 +-ATPase), neurotoxicity (AChE activity), oxidative stress (SOD, CAT and GPXs activities), metal exposure (metallothionein-like proteins - MTLP), biotransformation (GST), oxidative damage (LPO) and genotoxicity (DNA damage), were selected as endpoints to evaluate the sublethal responses of the ragworms after 14-days of exposure in a water-sediment system. Significant burrowing impairment occurred in worms exposed to the highest CisPt concentration (100 ng Pt L− 1) along with neurotoxic effects. The activity of antioxidant enzymes (SOD, CAT) and second phase biotransformation enzyme (GST) was inhibited but such effects were compensated by MTLP induction. Furthermore, LPO levels also increased. Results showed that the mode of action of cisplatin may pose a risk to this aquatic species even at the range of ng L− 1." @default.
- W1988323278 created "2016-06-24" @default.
- W1988323278 creator A5032720437 @default.
- W1988323278 creator A5047166654 @default.
- W1988323278 date "1997-01-01" @default.
- W1988323278 modified "2023-09-24" @default.
- W1988323278 title "Anoxic or aerial survival of bivalves and other euryoxic invertebrates as a useful response to environmental stress—a comprehensive review. De Netherlands Institute of Ecology, Centre for Estuarine/Coastal Ecology, Vierstraat 28, 4401 EA Yerseke, The Netherlands. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 1996, 113/2 (299–312). Summ. in Engl." @default.
- W1988323278 doi "https://doi.org/10.1016/s0269-7491(97)88471-0" @default.
- W1988323278 hasPublicationYear "1997" @default.
- W1988323278 type Work @default.
- W1988323278 sameAs 1988323278 @default.
- W1988323278 citedByCount "0" @default.
- W1988323278 crossrefType "journal-article" @default.
- W1988323278 hasAuthorship W1988323278A5032720437 @default.
- W1988323278 hasAuthorship W1988323278A5047166654 @default.
- W1988323278 hasConcept C107872376 @default.
- W1988323278 hasConcept C115346097 @default.
- W1988323278 hasConcept C121587506 @default.
- W1988323278 hasConcept C178790620 @default.
- W1988323278 hasConcept C181199279 @default.
- W1988323278 hasConcept C185592680 @default.
- W1988323278 hasConcept C18903297 @default.
- W1988323278 hasConcept C2776151105 @default.
- W1988323278 hasConcept C2776694085 @default.
- W1988323278 hasConcept C2778239845 @default.
- W1988323278 hasConcept C2778959862 @default.
- W1988323278 hasConcept C2779491297 @default.
- W1988323278 hasConcept C2781123465 @default.
- W1988323278 hasConcept C27881333 @default.
- W1988323278 hasConcept C29730261 @default.
- W1988323278 hasConcept C33070731 @default.
- W1988323278 hasConcept C54355233 @default.
- W1988323278 hasConcept C55493867 @default.
- W1988323278 hasConcept C86803240 @default.
- W1988323278 hasConcept C98274493 @default.
- W1988323278 hasConceptScore W1988323278C107872376 @default.
- W1988323278 hasConceptScore W1988323278C115346097 @default.
- W1988323278 hasConceptScore W1988323278C121587506 @default.
- W1988323278 hasConceptScore W1988323278C178790620 @default.
- W1988323278 hasConceptScore W1988323278C181199279 @default.
- W1988323278 hasConceptScore W1988323278C185592680 @default.
- W1988323278 hasConceptScore W1988323278C18903297 @default.
- W1988323278 hasConceptScore W1988323278C2776151105 @default.
- W1988323278 hasConceptScore W1988323278C2776694085 @default.
- W1988323278 hasConceptScore W1988323278C2778239845 @default.
- W1988323278 hasConceptScore W1988323278C2778959862 @default.
- W1988323278 hasConceptScore W1988323278C2779491297 @default.
- W1988323278 hasConceptScore W1988323278C2781123465 @default.
- W1988323278 hasConceptScore W1988323278C27881333 @default.
- W1988323278 hasConceptScore W1988323278C29730261 @default.
- W1988323278 hasConceptScore W1988323278C33070731 @default.
- W1988323278 hasConceptScore W1988323278C54355233 @default.
- W1988323278 hasConceptScore W1988323278C55493867 @default.
- W1988323278 hasConceptScore W1988323278C86803240 @default.
- W1988323278 hasConceptScore W1988323278C98274493 @default.
- W1988323278 hasIssue "1-2" @default.
- W1988323278 hasLocation W19883232781 @default.
- W1988323278 hasOpenAccess W1988323278 @default.
- W1988323278 hasPrimaryLocation W19883232781 @default.
- W1988323278 hasRelatedWork W1965459058 @default.
- W1988323278 hasRelatedWork W1978198695 @default.
- W1988323278 hasRelatedWork W2050351828 @default.
- W1988323278 hasRelatedWork W2462994204 @default.
- W1988323278 hasRelatedWork W2530814929 @default.
- W1988323278 hasRelatedWork W2902907173 @default.
- W1988323278 hasRelatedWork W3127409365 @default.
- W1988323278 hasRelatedWork W4297019876 @default.
- W1988323278 hasRelatedWork W4308499098 @default.
- W1988323278 hasRelatedWork W4321793368 @default.
- W1988323278 hasVolume "97" @default.
- W1988323278 isParatext "false" @default.
- W1988323278 isRetracted "false" @default.
- W1988323278 magId "1988323278" @default.
- W1988323278 workType "article" @default.