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• W1988347105 abstract "Testosterone (T) and the androgen receptor (AR) are involved in mechanisms associated with hypertension and vessel reactivity.To investigate T and the AR on blood vessel reactivity, testicular feminized male (TFM; AR deficient males) and normal androgen receptor (NAR) male rats were used. Therefore, if the functional AR is necessary for plasma T to regulate vessel responsiveness, TFM males will exhibit altered vessel function compared to NAR males.Adult (16 weeks of age) TFM or NAR males were assigned to the following treatment groups: gonadal intact controls (CONT), castrate (CAST), or castrate with T replacement (CAST+T) with (n=8-10/group).Plasma T followed a consistent pattern with CAST+T elevated compared to CONT and CAST TFM and NAR males. In addition, CAST plasma T was significantly decreased compared to CONT and CAST+T in TFM and NAR males. In a similar manner for systolic blood pressure (SBP), CAST lowered SBP compared to CONT in both NAR and TFM. Following 8 weeks of treatment, second-order mesenteric artery responses to changes in intraluminal pressure (myogenic reactivity) were analyzed using a pressure arteriograph system. Both TFM (P < 0.05) and NAR (P < 0.05) CAST groups revealed a decrease in myogenic reactivity compared to CONT. Following T treatment the TFM CAST+T myogenic reactivity returned to CONT levels, whereas the NAR CAST+T myogenic reactivity increased a further 10%.The results of this study indicate that T differentially regulates mesenteric artery reactivity in TFM and NAR males. Our data also demonstrate that both AR and/or non-AR mediated mechanisms may partially contribute to SBP regulation." @default.
• W1988347105 created "2016-06-24" @default.
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• W1988347105 date "2011-02-01" @default.
• W1988347105 modified "2023-09-25" @default.
• W1988347105 title "Testosterone Increases Myogenic Reactivity of Second-Order Mesenteric Arteries in both Defective and Normal Androgen Receptor Adult Male Rats" @default.
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• W1988347105 doi "https://doi.org/10.1016/j.genm.2011.01.002" @default.
• W1988347105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21497771" @default.
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