FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988351609> ?p ?o ?g. }

• W1988351609 endingPage "63" @default.
• W1988351609 startingPage "53" @default.
• W1988351609 abstract "Vaccinia virus (VV) is considered to cause lytic infection of most cells, with lysis being regarded equivalent to necrosis. Activation of caspases has not been associated with necrosis. However, we observed the activation and activity of caspases in epithelial cells HeLa G and BSC-40 lytically infected with VV. Using three different flow-cytometric approaches, we characterized the distinct stages of caspase cascade in VV-infected cells: a cleaved, activated form of caspases detected using a fluorescent pan-caspase inhibitor; caspase activity assayed by cleavage of a non-fluorescent substrate into a fluorescent product; caspase-specific cleavage of death substrates characterized by a fluorescent antibody detecting a neo-epitope in cytokeratin-18. All of these approaches yielded an increased fluorescent signal in VV-infected cells compared to mock-infected controls. Additionally, the signal was decreased by the expression of Bcl-2. The cleavage of cytokeratin-18 was confirmed by western blotting, but another key protein involved in apoptosis, PARP, was not cleaved in VV-infected lytic cells. The necrotic phenotype of the cells was confirmed by increased cell membrane permeability and/or decreased mitochondrial membrane potential. In conclusion, our data suggest that VV infection of the epithelial cells HeLa G and BSC-40 initiates the apoptotic program, however, apoptosis is not completed and switches into necrosis." @default.
• W1988351609 created "2016-06-24" @default.
• W1988351609 creator A5000550999 @default.
• W1988351609 creator A5025447193 @default.
• W1988351609 creator A5033932983 @default.
• W1988351609 creator A5037879238 @default.
• W1988351609 date "2008-07-01" @default.
• W1988351609 modified "2023-10-13" @default.
• W1988351609 title "Lytic infection with vaccinia virus activates caspases in a Bcl-2-inhibitable manner" @default.
• W1988351609 cites W1497632326 @default.
• W1988351609 cites W1502236509 @default.
• W1988351609 cites W1513849159 @default.
• W1988351609 cites W1517755581 @default.
• W1988351609 cites W1556541087 @default.
• W1988351609 cites W1607777232 @default.
• W1988351609 cites W1919607390 @default.
• W1988351609 cites W1950362618 @default.
• W1988351609 cites W1960031454 @default.
• W1988351609 cites W1969601100 @default.
• W1988351609 cites W1980109110 @default.
• W1988351609 cites W1981417014 @default.
• W1988351609 cites W1983476428 @default.
• W1988351609 cites W1993614010 @default.
• W1988351609 cites W1995533883 @default.
• W1988351609 cites W1995935153 @default.
• W1988351609 cites W1998519004 @default.
• W1988351609 cites W2001558423 @default.
• W1988351609 cites W2010413886 @default.
• W1988351609 cites W2012044647 @default.
• W1988351609 cites W2019817345 @default.
• W1988351609 cites W2020644019 @default.
• W1988351609 cites W2021213516 @default.
• W1988351609 cites W2033793539 @default.
• W1988351609 cites W2034305943 @default.
• W1988351609 cites W2046198496 @default.
• W1988351609 cites W2047022250 @default.
• W1988351609 cites W2049179639 @default.
• W1988351609 cites W2052026210 @default.
• W1988351609 cites W2055817487 @default.
• W1988351609 cites W2056043388 @default.
• W1988351609 cites W2059172089 @default.
• W1988351609 cites W2090759029 @default.
• W1988351609 cites W2097786201 @default.
• W1988351609 cites W2100837269 @default.
• W1988351609 cites W2109252620 @default.
• W1988351609 cites W2113411351 @default.
• W1988351609 cites W2134158036 @default.
• W1988351609 cites W2137420064 @default.
• W1988351609 cites W2140955159 @default.
• W1988351609 cites W2142911981 @default.
• W1988351609 cites W2144485902 @default.
• W1988351609 cites W2164549555 @default.
• W1988351609 cites W2172039135 @default.
• W1988351609 cites W2316285318 @default.
• W1988351609 cites W2320101893 @default.
• W1988351609 doi "https://doi.org/10.1016/j.virusres.2008.02.007" @default.
• W1988351609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18405998" @default.
• W1988351609 hasPublicationYear "2008" @default.
• W1988351609 type Work @default.
• W1988351609 sameAs 1988351609 @default.
• W1988351609 citedByCount "6" @default.
• W1988351609 countsByYear W19883516092012 @default.
• W1988351609 countsByYear W19883516092014 @default.
• W1988351609 countsByYear W19883516092019 @default.
• W1988351609 countsByYear W19883516092021 @default.
• W1988351609 crossrefType "journal-article" @default.
• W1988351609 hasAuthorship W1988351609A5000550999 @default.
• W1988351609 hasAuthorship W1988351609A5025447193 @default.
• W1988351609 hasAuthorship W1988351609A5033932983 @default.
• W1988351609 hasAuthorship W1988351609A5037879238 @default.
• W1988351609 hasConcept C12519072 @default.
• W1988351609 hasConcept C1491633281 @default.
• W1988351609 hasConcept C153911025 @default.
• W1988351609 hasConcept C159047783 @default.
• W1988351609 hasConcept C182615771 @default.
• W1988351609 hasConcept C190283241 @default.
• W1988351609 hasConcept C203014093 @default.
• W1988351609 hasConcept C204232928 @default.
• W1988351609 hasConcept C2522874641 @default.
• W1988351609 hasConcept C2777366897 @default.
• W1988351609 hasConcept C2779012181 @default.
• W1988351609 hasConcept C29311851 @default.
• W1988351609 hasConcept C31573885 @default.
• W1988351609 hasConcept C55493867 @default.
• W1988351609 hasConcept C86803240 @default.
• W1988351609 hasConcept C95444343 @default.
• W1988351609 hasConcept C98424977 @default.
• W1988351609 hasConceptScore W1988351609C12519072 @default.
• W1988351609 hasConceptScore W1988351609C1491633281 @default.
• W1988351609 hasConceptScore W1988351609C153911025 @default.
• W1988351609 hasConceptScore W1988351609C159047783 @default.
• W1988351609 hasConceptScore W1988351609C182615771 @default.
• W1988351609 hasConceptScore W1988351609C190283241 @default.
• W1988351609 hasConceptScore W1988351609C203014093 @default.
• W1988351609 hasConceptScore W1988351609C204232928 @default.
• W1988351609 hasConceptScore W1988351609C2522874641 @default.
• W1988351609 hasConceptScore W1988351609C2777366897 @default.
• W1988351609 hasConceptScore W1988351609C2779012181 @default.

• next