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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988357430> ?p ?o ?g. }

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• W1988357430 abstract "Rapidly accumulating evidence indicates that inflammatory T cells sensitively respond to their redox environment by activating signal transduction pathways. The hypothesis that T-cell receptors have the potential to catalytically transform singlet oxygen into H(2)O(2) attracted our attention since the biophysical regulation of this process would provide a new tool for therapeutically directing T cells down a preferred signaling pathway. Light-dependent production of H(2)O(2) was first described in antibodies, and we reproduced these findings. Using a real-time H(2)O(2) sensor we extended them by showing that the reaction proceeds in a biphasic way with a short-lived phase that is fast compared to the slow second phase of the reaction. We then showed that Jurkat T cells biophotonically produce about 30nM H(2)O(2)/min/mg protein when pretreated with NaN(3). This activity was concentrated 4 to 5 times in T-cell membrane preparations. The implications of these observations for the development of new therapeutic tools for inflammatory diseases are discussed." @default.
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• W1988357430 date "2005-12-01" @default.
• W1988357430 modified "2023-09-27" @default.
• W1988357430 title "Biophotonic hydrogen peroxide production by antibodies, T cells, and T-cell membranes" @default.
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• W1988357430 doi "https://doi.org/10.1016/j.bbrc.2005.10.037" @default.
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