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• W1988357583 endingPage "1527" @default.
• W1988357583 startingPage "1517" @default.
• W1988357583 abstract "The present investigation was undertaken to characterize the Na+/K+ pump current in small (25 μm in soma diameter) dorsal root ganglion (DRG) neurons isolated from lumbar L4-6 segments of adult rats. The Na+/K+ pump current was identified as an ouabain-sensitive current during square voltage steps to membrane potentials between +40 and −120 mV, using the whole-cell patch-clamp technique in which Ca2+ and K+ channel currents and Na+/Ca2+ exchange currents were minimized. The Na+/K+ pump current was practically time-independent over the entire voltage range examined and exhibited a voltage-dependence; its current – voltage (I–V) relationship displayed a positive slope at potentials between −120 and 0 mV but nearly plateau levels at positive membrane potentials. The concentration-dependent block of Na+/K+ pump current (activated by 30 mM pipette Na+) by ouabain at concentrations between 0.1 μM and 5 mM was biphasic and was well described using a two-binding site model with dissociation constants for high- and low-affinity binding sites of 0.20 and 140.1 μM, respectively. The relative amplitude of the Na+/K+ pump current produced by low- and high-affinity sites (probably α1β1 and α3β1 isozymes, respectively) was estimated to be 13 : 1 in the presence of 30 mM Na+ in the pipette solution. Additionally, the activation of Na+/K+ pump current by pipette Na+ at concentrations ranging from 5 to 100 mM also exhibited a biphasic concentration dependence which can be reasonably well fitted by assuming the existence of two isozymes having high and low affinities for Na+ (6.7 and 67.6 mM, respectively). Thus, the present investigation provides functional evidence to suggest that the Na+/K+ ATPase comprises two functionally distinct isozymes as expected for α1β1 and α3β1 in rat small DRG neurons. British Journal of Pharmacology (2003) 138, 1517–1527. doi:10.1038/sj.bjp.0705170" @default.
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• W1988357583 date "2003-04-01" @default.
• W1988357583 modified "2023-10-14" @default.
• W1988357583 title "Properties of the Na⁺/K⁺pump current in small neurons from adult rat dorsal root ganglia" @default.
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• W1988357583 doi "https://doi.org/10.1038/sj.bjp.0705170" @default.
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