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- W1988360065 abstract "A case of short P-R interval and prolonged QRS complex is presented. On repeated occasions the abnormal electrocardiogram was transformed into a normal one by the oral administration of quinidine. Cholinergic drugs, including digitalis, when administered soon after the appearance of the normal electrocardiographic pattern, reproduced the abnormal pattern. These observations are in harmony with the hypothesis that the abnormal electrocardiographic pattern is due to an accessory auriculoventricular conduction mechanism. Quinidine sulfate apparently has a greater affinity for the accessory tissue, and depresses it, thus allowing transmission of the sinus impulse through the normal pathway, whereas the cholinergic drugs (including digitalis), by depressing the A-V node, divert the impulse through the aberrant conduction tissue." @default.
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- W1988360065 date "1944-09-01" @default.
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- W1988360065 title "On the mechanism of the electrocardiographic syndrome of short P-R interval with prolonged QRS complex" @default.
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- W1988360065 doi "https://doi.org/10.1016/s0002-8703(44)90091-8" @default.
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