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- W1988367009 abstract "The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. It is suggested that these pathways, together with other biochemical anomalies arising from hyperglycaemia, can synergise by sharing the capacity to activate mitogen-activated protein kinases (MAP kinases) and that these enzymes in actual fact form glucose transducers. The more recent hypothesis, namely that activation of a specific isoform of protein kinase C (PKC) underpin damaging changes in retinopathy and neuropathy, can also be related because protein kinase C is an effective activator of mitogen-activated protein kinases. These latter kinases phosphorylate transcription factors, which in turn alter the balance of gene expression. In this way they can alter cellular phenotype, promote division or increase production of extracellular material. In short, mitogen-activated protein kinases have the capacity to trigger all the cellular events necessary for the development of diabetic nephropathy, retinopathy and neuropathy and it is suggested that their pharmacological modulation might provide therapeutic control of these conditions. [Diabetologia (1999) 42: 1271-1281]" @default.
- W1988367009 created "2016-06-24" @default.
- W1988367009 creator A5057795207 @default.
- W1988367009 date "1999-10-19" @default.
- W1988367009 modified "2023-09-24" @default.
- W1988367009 title "Mitogen-activated protein kinases as glucose transducers for diabetic complications" @default.
- W1988367009 cites W1482963297 @default.
- W1988367009 cites W1490762411 @default.
- W1988367009 cites W1510592624 @default.
- W1988367009 cites W1565144839 @default.
- W1988367009 cites W1597393973 @default.
- W1988367009 cites W1607304197 @default.
- W1988367009 cites W16443402 @default.
- W1988367009 cites W1810991871 @default.
- W1988367009 cites W1811191752 @default.
- W1988367009 cites W1853675660 @default.
- W1988367009 cites W1868769527 @default.
- W1988367009 cites W1936913048 @default.
- W1988367009 cites W1966322286 @default.
- W1988367009 cites W1966778168 @default.
- W1988367009 cites W1971453983 @default.
- W1988367009 cites W1971946365 @default.
- W1988367009 cites W1973321701 @default.
- W1988367009 cites W1975974235 @default.
- W1988367009 cites W1977192281 @default.
- W1988367009 cites W1977472414 @default.
- W1988367009 cites W1978798502 @default.
- W1988367009 cites W1979814082 @default.
- W1988367009 cites W1980735721 @default.
- W1988367009 cites W1980901172 @default.
- W1988367009 cites W1981584197 @default.
- W1988367009 cites W1982491014 @default.
- W1988367009 cites W1984623452 @default.
- W1988367009 cites W1985789399 @default.
- W1988367009 cites W1986559713 @default.
- W1988367009 cites W1987298734 @default.
- W1988367009 cites W1988604934 @default.
- W1988367009 cites W1989480480 @default.
- W1988367009 cites W1992014029 @default.
- W1988367009 cites W1993046527 @default.
- W1988367009 cites W1993816916 @default.
- W1988367009 cites W1993902553 @default.
- W1988367009 cites W1996182204 @default.
- W1988367009 cites W1997218197 @default.
- W1988367009 cites W1998430334 @default.
- W1988367009 cites W2000076269 @default.
- W1988367009 cites W2000389046 @default.
- W1988367009 cites W2000892619 @default.
- W1988367009 cites W2001399809 @default.
- W1988367009 cites W2002735036 @default.
- W1988367009 cites W2005900169 @default.
- W1988367009 cites W2007155435 @default.
- W1988367009 cites W2007986629 @default.
- W1988367009 cites W2012713267 @default.
- W1988367009 cites W2013073021 @default.
- W1988367009 cites W2014054225 @default.
- W1988367009 cites W2015471917 @default.
- W1988367009 cites W2018093451 @default.
- W1988367009 cites W2023312698 @default.
- W1988367009 cites W2030499688 @default.
- W1988367009 cites W2032582358 @default.
- W1988367009 cites W2032984787 @default.
- W1988367009 cites W2033467435 @default.
- W1988367009 cites W2034280068 @default.
- W1988367009 cites W2035592628 @default.
- W1988367009 cites W2038233386 @default.
- W1988367009 cites W2039558513 @default.
- W1988367009 cites W2039829780 @default.
- W1988367009 cites W2040720408 @default.
- W1988367009 cites W2041490149 @default.
- W1988367009 cites W2044524894 @default.
- W1988367009 cites W2047964022 @default.
- W1988367009 cites W2048306311 @default.
- W1988367009 cites W2051361241 @default.
- W1988367009 cites W2053383702 @default.
- W1988367009 cites W2054179928 @default.
- W1988367009 cites W2055149392 @default.
- W1988367009 cites W2057464262 @default.
- W1988367009 cites W2061007739 @default.
- W1988367009 cites W2064068403 @default.
- W1988367009 cites W2065509427 @default.
- W1988367009 cites W2066108602 @default.
- W1988367009 cites W2067246958 @default.
- W1988367009 cites W2068465288 @default.
- W1988367009 cites W2069132844 @default.
- W1988367009 cites W2073691281 @default.
- W1988367009 cites W2074527199 @default.
- W1988367009 cites W2074712105 @default.
- W1988367009 cites W2076672919 @default.
- W1988367009 cites W2078083049 @default.
- W1988367009 cites W2082141855 @default.
- W1988367009 cites W2089246217 @default.
- W1988367009 cites W2091758977 @default.
- W1988367009 cites W2091851800 @default.
- W1988367009 cites W2092716869 @default.
- W1988367009 cites W2098207604 @default.
- W1988367009 cites W2107771216 @default.
- W1988367009 cites W2111793581 @default.