Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988368768> ?p ?o ?g. }
- W1988368768 endingPage "324" @default.
- W1988368768 startingPage "316" @default.
- W1988368768 abstract "The gut harbors the largest immune system in the body. The mucosa is considered to be the initial site of interaction with commensal and pathogenic organisms; therefore, it is the first line of defense against the pathogens. In response to the invasion of various pathogens, naïve CD4+ cells differentiate into subsets of T helper (Th) cells that are characterized by different cytokine profiles. Cytokines bind to cell surface receptors on both immune and non-immune cells leading to activation of JAK-STAT signaling pathway and influence gut function by up-regulating the expression of specific target genes. This review considers the roles of cytokines and receptor-mediated activation of STATs on pathogen-induced changes in gut function. The focus on STAT4 and STAT6 is because of their requirement for the full development of Th1 and Th2 cytokine profiles." @default.
- W1988368768 created "2016-06-24" @default.
- W1988368768 creator A5042622786 @default.
- W1988368768 creator A5046243234 @default.
- W1988368768 creator A5046930712 @default.
- W1988368768 creator A5090807587 @default.
- W1988368768 date "2010-09-01" @default.
- W1988368768 modified "2023-10-06" @default.
- W1988368768 title "Enteric pathogens and gut function: Role of cytokines and STATs" @default.
- W1988368768 cites W1502422472 @default.
- W1988368768 cites W1537063289 @default.
- W1988368768 cites W1543204600 @default.
- W1988368768 cites W1552340624 @default.
- W1988368768 cites W1573332955 @default.
- W1988368768 cites W1578692400 @default.
- W1988368768 cites W1590951668 @default.
- W1988368768 cites W1603996693 @default.
- W1988368768 cites W1648195341 @default.
- W1988368768 cites W1693692513 @default.
- W1988368768 cites W1775935655 @default.
- W1988368768 cites W1825772180 @default.
- W1988368768 cites W1828221682 @default.
- W1988368768 cites W1882823390 @default.
- W1988368768 cites W1964052073 @default.
- W1988368768 cites W1966710274 @default.
- W1988368768 cites W1971603261 @default.
- W1988368768 cites W1978994454 @default.
- W1988368768 cites W1980702664 @default.
- W1988368768 cites W1984159720 @default.
- W1988368768 cites W1985293294 @default.
- W1988368768 cites W1989845608 @default.
- W1988368768 cites W2000024124 @default.
- W1988368768 cites W2003508538 @default.
- W1988368768 cites W2004721639 @default.
- W1988368768 cites W2006876455 @default.
- W1988368768 cites W2007252917 @default.
- W1988368768 cites W2009053589 @default.
- W1988368768 cites W2009887653 @default.
- W1988368768 cites W2010016797 @default.
- W1988368768 cites W2011157287 @default.
- W1988368768 cites W2015516540 @default.
- W1988368768 cites W2016045507 @default.
- W1988368768 cites W2019002715 @default.
- W1988368768 cites W2024005495 @default.
- W1988368768 cites W2027995647 @default.
- W1988368768 cites W2029275361 @default.
- W1988368768 cites W2032799815 @default.
- W1988368768 cites W2033203646 @default.
- W1988368768 cites W2044153433 @default.
- W1988368768 cites W2046317156 @default.
- W1988368768 cites W2047081723 @default.
- W1988368768 cites W2050604953 @default.
- W1988368768 cites W2051724792 @default.
- W1988368768 cites W2056782399 @default.
- W1988368768 cites W2060527543 @default.
- W1988368768 cites W2070120800 @default.
- W1988368768 cites W2070242833 @default.
- W1988368768 cites W2073007458 @default.
- W1988368768 cites W2076588832 @default.
- W1988368768 cites W2078841246 @default.
- W1988368768 cites W2083802827 @default.
- W1988368768 cites W2084111853 @default.
- W1988368768 cites W2088236771 @default.
- W1988368768 cites W2088812171 @default.
- W1988368768 cites W2088998131 @default.
- W1988368768 cites W2097714368 @default.
- W1988368768 cites W2098212461 @default.
- W1988368768 cites W2098615045 @default.
- W1988368768 cites W2102182822 @default.
- W1988368768 cites W2105479815 @default.
- W1988368768 cites W2108014005 @default.
- W1988368768 cites W2110015632 @default.
- W1988368768 cites W2110672879 @default.
- W1988368768 cites W2115496765 @default.
- W1988368768 cites W2115545988 @default.
- W1988368768 cites W2118140057 @default.
- W1988368768 cites W2118752824 @default.
- W1988368768 cites W2123307326 @default.
- W1988368768 cites W2129011493 @default.
- W1988368768 cites W2130982757 @default.
- W1988368768 cites W2131599301 @default.
- W1988368768 cites W2132703507 @default.
- W1988368768 cites W2135900836 @default.
- W1988368768 cites W2136232392 @default.
- W1988368768 cites W2139712080 @default.
- W1988368768 cites W2145488426 @default.
- W1988368768 cites W2146671478 @default.
- W1988368768 cites W2152674644 @default.
- W1988368768 cites W2152978188 @default.
- W1988368768 cites W2154096824 @default.
- W1988368768 cites W2156451877 @default.
- W1988368768 cites W2158591788 @default.
- W1988368768 cites W2162668126 @default.
- W1988368768 cites W2165203861 @default.
- W1988368768 cites W2165658685 @default.
- W1988368768 cites W2171010912 @default.
- W1988368768 doi "https://doi.org/10.4161/gmic.1.5.13329" @default.
- W1988368768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3023616" @default.