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• W1988369548 abstract "Modified analogues of antisense oligodeoxynucleotides (ODNs), particularly phosphorothioates ([S]ODNs), have been extensively used to inhibit gene expression. The potential sequence specificity of antisense oligomers makes them attractive as molecular drugs for human diseases. The use of antisense [S]ODNs to inhibit gene expression has been complicated by frequent nonspecific effects. In this study we show in diverse cell types that [S]ODNs, independent of their base sequence, mediated the induction of an Sp1 nuclear transcription factor. The [S]ODN-mediated Sp1 induction was rapid and was associated with elevated levels of Sp1 protein. This induction was dependent on NF-kappa B activity, since inhibition of NF-kappa B activity abolished the [S]ODN-induced Sp1 activity. [S]ODN-induced Sp1 activity was seen in mouse spleen cells following in vivo administration. Sp1 activity induced by [S]ODNs required the tyrosine kinase pathway and did not have transactivating potential. These results may help to explain some of the non-specific effects often seen with [S]ODNs." @default.
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• W1988369548 date "1994-06-21" @default.
• W1988369548 modified "2023-10-18" @default.
• W1988369548 title "Sequence-independent induction of Sp1 transcription factor activity by phosphorothioate oligodeoxynucleotides." @default.
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• W1988369548 doi "https://doi.org/10.1073/pnas.91.13.5957" @default.
• W1988369548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44116" @default.
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