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• W1988376488 abstract "Significance In spite of the large number of biochemical studies contributing to the analysis of Ras-mediated cell cycle regulation, we do not know how Ras signaling controls the cell cycle. Here, we used an unbiased genetic approach to unveil essential components of Ras-mediated proliferation. Our results reveal that Ras signaling induces cell proliferation by a mechanism that requires inactivation of the p53/p21 Cdk-interacting protein 1 (Cip1) axis by preventing acetylation of specific p53 lysine residues. More importantly, loss of p53 or p21Cip1 can sustain cell proliferation in the absence of Ras proteins via Ras-independent activation of the Raf/Mek/Erk cascade. These results may have important implications for tumor growth and treatment, because activation of Ras oncogenes and inactivation of p53 are frequent events in human cancer." @default.
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• W1988376488 date "2014-10-06" @default.
• W1988376488 modified "2023-10-15" @default.
• W1988376488 title "Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway" @default.
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• W1988376488 doi "https://doi.org/10.1073/pnas.1417549111" @default.
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